PMID- 8835664
OWN - NLM
STAT- MEDLINE
DCOM- 19970204
LR  - 20190512
IS  - 0146-4760 (Print)
IS  - 0146-4760 (Linking)
VI  - 20
IP  - 4
DP  - 1996 Jul-Aug
TI  - Detection and quantitation of amphetamine and methamphetamine: electron impact 
      and chemical ionization with ammonia--comparative investigation on Shimadzu QP 
      5000 GC-MS system.
PG  - 255-61
AB  - Gas chromatographic-mass spectrometric (GC-MS) analyses of amphetamine and 
      methamphetamine with chemical ionization (CI) (NH3) and electron impact (EI) were 
      compared after solid-phase extraction from urine. The optimal CI (NH3) conditions 
      for amphetamines were selected; the CI mass spectra of amphetamine, 
      methamphetamine, methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine 
      (MDMA), and methylenedioxyethylamphetamine (MDEA) were obtained. Amphetamine and 
      methamphetamine were monitored as [M+H]+ ions in SIM mode. Under these conditions 
      the GC-MS limits of detection and quantitation were determined for amphetamine 
      (2.1 and 5.0 mg/L, respectively) and for methamphetamine (0.9 and 2.0 mg/L, 
      respectively). The heptafluorobutanoyl (HFB) derivatives were used to increase 
      the sensitivity of the GC-MS analysis of amphetamines. Under CI (NH3) conditions 
      these compounds form mainly the cluster ions [M+NH4]+. For HFB-derivatives the 
      limits of detection and quantitation for CI (NH3) were 95 and 170 micrograms/L, 
      respectively, for amphetamine (m/z 349) and 90 and 160 micrograms/L, 
      respectively, for methamphetamine (m/z 363). For EI they were 10 and 30 
      micrograms/L, respectively, for amphetamine (m/z 240) and 9 and 27 micrograms/L, 
      respectively, for methamphetamine (m/z 254). The GC-MS-CI (NH3) technique was 
      found to be suitable for confirmation of amphetamine and methamphetamine in urine 
      samples in addition to the routine GC-MS-EI method.
FAU - Dallakian, P
AU  - Dallakian P
AD  - Institut fur Organische Chemie der Universitat zu Koln, Koln, Germany.
FAU - Budzikiewicz, H
AU  - Budzikiewicz H
FAU - Brzezinka, H
AU  - Brzezinka H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 44RAL3456C (Methamphetamine)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/*isolation & purification/*urine
MH  - Gas Chromatography-Mass Spectrometry/instrumentation/methods
MH  - Humans
MH  - Methamphetamine/*isolation & purification/*urine
MH  - Reference Values
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1093/jat/20.4.255 [doi]
PST - ppublish
SO  - J Anal Toxicol. 1996 Jul-Aug;20(4):255-61. doi: 10.1093/jat/20.4.255.