PMID- 8835818
OWN - NLM
STAT- MEDLINE
DCOM- 19961210
LR  - 20190914
IS  - 0904-2512 (Print)
IS  - 0904-2512 (Linking)
VI  - 25
IP  - 5
DP  - 1996 May
TI  - Is there a role for tumor necrosis factor-alpha (TNF-alpha) in oral lichen 
      planus?
PG  - 219-24
AB  - Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral 
      mucosa. T lymphocytes accumulate within OLP lesions by extravasation from the 
      local microvasculature and subsequent migration to the oral epithelium. Tumor 
      necrosis factor-alpha (TNF-alpha) is a cytokine involved primarily in T 
      cell-mediated immunopathological reactions, and it is implicated in diseases 
      which bear clinical and histological similarities to OLP. This review examines 
      the role of TNF-alpha in the initiation and progression of OLP, and summarises 
      evidence for a key role for TNF-alpha in this disease. A unifying hypothesis for 
      the involvement of TNF-alpha in the immunopathogenesis of OLP is presented. Based 
      on this model, a variety of current therapies are explained and several 
      alternative approaches suggested.
FAU - Sugermann, P B
AU  - Sugermann PB
AD  - Department of Dentistry, University of Queensland, Brisbane, Australia.
FAU - Savage, N W
AU  - Savage NW
FAU - Seymour, G J
AU  - Seymour GJ
FAU - Walsh, L J
AU  - Walsh LJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Cell Movement
MH  - Disease Progression
MH  - Epithelium/immunology
MH  - Humans
MH  - Immunotherapy
MH  - Lichen Planus, Oral/*immunology/therapy
MH  - Lymphocyte Activation
MH  - Microcirculation
MH  - Mouth Mucosa/blood supply
MH  - T-Lymphocytes/immunology
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors/*immunology
RF  - 81
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
AID - 10.1111/j.1600-0714.1996.tb01375.x [doi]
PST - ppublish
SO  - J Oral Pathol Med. 1996 May;25(5):219-24. doi: 
      10.1111/j.1600-0714.1996.tb01375.x.