PMID- 8836541
OWN - NLM
STAT- MEDLINE
DCOM- 19970213
LR  - 20131121
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 726
IP  - 1-2
DP  - 1996 Jul 8
TI  - Activation of iron handling system within the gerbil hippocampus after cerebral 
      ischemia.
PG  - 23-30
AB  - Analyzing the distribution pattern of transferrin (Tf) and ferritin, we 
      investigated the changes in iron metabolism related proteins in the process of 
      neuronal death induced by 5 min ischemia. In the control animals, Tf 
      immunoreactivity was localized in the oligodendrocytes. Ferritin was distributed 
      in both neurons and gliacytes, particularly microglia. In parallel with the 
      delayed neuronal death, Tf-positive atrophied neurons and numerous 
      ferritin-positive gliacytes appeared in the CA1 subfield of the hippocampus 4 
      days after ischemia, when glia fibrillary acidic protein (GFAP)-positive 
      astrocytes also appeared throughout the hippocampal structure. A considerable 
      number of ferritin-positive phagocytes (reactive microglia) appeared in the 
      stratum pyramidale from the seventh day. Our data show clearly that the 
      mobilization of Tf and ferritin-positive phagocytes are linked with the 
      degeneration of neurons induced by cerebral ischemia. These events may suggest an 
      activation of iron handling system under the postischemic condition.
FAU - Ishimaru, H
AU  - Ishimaru H
AD  - Department of Neuropsychopharmacology (Tsumura), Gunma University School of 
      Medicine, Japan.
FAU - Ishikawa, K
AU  - Ishikawa K
FAU - Ohe, Y
AU  - Ohe Y
FAU - Takahashi, A
AU  - Takahashi A
FAU - Tatemoto, K
AU  - Tatemoto K
FAU - Maruyama, Y
AU  - Maruyama Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Animals
MH  - Antibody Specificity
MH  - Atrophy/metabolism
MH  - Ferritins/analysis
MH  - Gerbillinae
MH  - Glial Fibrillary Acidic Protein/analysis
MH  - Immunohistochemistry
MH  - Iron/*metabolism
MH  - Ischemic Attack, Transient/*metabolism/pathology
MH  - Male
MH  - Nerve Tissue Proteins/analysis
MH  - Prosencephalon/*blood supply
MH  - Pyramidal Cells/*metabolism/pathology
EDAT- 1996/07/08 00:00
MHDA- 1996/07/08 00:01
CRDT- 1996/07/08 00:00
PHST- 1996/07/08 00:00 [pubmed]
PHST- 1996/07/08 00:01 [medline]
PHST- 1996/07/08 00:00 [entrez]
AID - 0006-8993(96)00294-6 [pii]
PST - ppublish
SO  - Brain Res. 1996 Jul 8;726(1-2):23-30.