PMID- 8837300
OWN - NLM
STAT- MEDLINE
DCOM- 19961217
LR  - 20191101
IS  - 0960-7404 (Print)
IS  - 0960-7404 (Linking)
VI  - 5
IP  - 1
DP  - 1996 Feb
TI  - Hepatocyte growth factor/scatter factor expression and c-met in primary breast 
      cancer.
PG  - 15-21
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is a fibroblast-derived cytokine 
      whose receptor is encoded by c-met. Activation of c-met promotes tumour cell 
      proliferation, dissociation, invasiveness and angiogenesis. Aberrant expression 
      of HGF/SF or c-met may play a role in tumour progression. HGF/SF and c-met were 
      determined in 73 breast cancers (median follow up: 61 months) and 10 samples of 
      tumour-free breast tissue. HGF/SF was detected at significantly higher 
      concentrations in breast cancers (median 350, range 58-1604 ng per 100 mg total 
      protein) when compared with normal breast tissue (median 108, range 66-213 ng per 
      100 mg total protein) (P < 0.001). C-met was detected in all 10 samples of 
      tumour-free breast tissue and in 26 breast cancers. HGF/SF concentrations 
      correlated with disease relapse (P < 0.001) and reduced overall survival (P < 
      0.001). Tumours with detectable c-met correlated significantly with 
      disease-relapse (P = 0.012). Multivariate analysis demonstrated a significant 
      interaction between HGF/SF and c-met in relation to disease-relapse (P = 0.014). 
      These results suggest a biological interaction involving HGF/SF and c-met in 
      promoting tumour progression in breast cancer.
FAU - Nagy, J
AU  - Nagy J
AD  - University Department of Surgery, Western Infirmary, Glasgow, UK.
FAU - Curry, G W
AU  - Curry GW
FAU - Hillan, K J
AU  - Hillan KJ
FAU - McKay, I C
AU  - McKay IC
FAU - Mallon, E
AU  - Mallon E
FAU - Purushotham, A D
AU  - Purushotham AD
FAU - George, W D
AU  - George WD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Surg Oncol
JT  - Surgical oncology
JID - 9208188
RN  - 0 (Proto-Oncogene Proteins)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Breast/metabolism
MH  - Breast Neoplasms/*genetics/pathology
MH  - Cell Division
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene Expression Regulation, Neoplastic
MH  - Hepatocyte Growth Factor/*genetics
MH  - Humans
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Invasiveness
MH  - Neoplasm Recurrence, Local/genetics
MH  - Neovascularization, Pathologic
MH  - Proto-Oncogene Proteins/*genetics
MH  - Proto-Oncogene Proteins c-met
MH  - Proto-Oncogenes/*genetics
MH  - Receptor Protein-Tyrosine Kinases/*genetics
MH  - Survival Rate
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - S0960-7404(96)80017-X [pii]
AID - 10.1016/s0960-7404(96)80017-x [doi]
PST - ppublish
SO  - Surg Oncol. 1996 Feb;5(1):15-21. doi: 10.1016/s0960-7404(96)80017-x.