PMID- 8837350
OWN - NLM
STAT- MEDLINE
DCOM- 19961213
LR  - 20190819
IS  - 0042-9007 (Print)
IS  - 0042-9007 (Linking)
VI  - 71
IP  - 1
DP  - 1996
TI  - The HLA system: an update and relevance to patient-donor matching strategies in 
      clinical transplantation.
PG  - 6-12
AB  - In recent years the development of recombinant DNA and sequencing techniques has 
      led to a greatly increased understanding of the genetic complexity, structure and 
      function of the human major histocompatibility complex. This system may be 
      subdivided into the "classical' HLA (human leukocyte antigen) class I and II 
      transplantation antigens and novel HLA and non-HLA genes, involved in antigen 
      processing and presentation to T cells. Parallel technological developments in 
      HLA DNA typing in the clinical laboratory have resulted in a more precise 
      awareness of the role of HLA matching for the classical HLA antigens in bone 
      marrow and solid organ transplantation, while alternative strategies and 
      techniques for donor selection are currently under evaluation. This review offers 
      a current perspective on the genetics, structure and function of the HLA system, 
      its relevance to clinical transplantation and future prospects for improvements 
      in donor selection.
FAU - Howell, W M
AU  - Howell WM
AD  - Wessex Histocompatibility Laboratory, Southampton University Hospitals, UK.
FAU - Navarrete, C
AU  - Navarrete C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Bone Marrow Transplantation/immunology
MH  - *HLA Antigens
MH  - Histocompatibility
MH  - Humans
MH  - Kidney Transplantation/immunology
MH  - *Major Histocompatibility Complex
RF  - 44
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1046/j.1423-0410.1996.7110006.x [doi]
PST - ppublish
SO  - Vox Sang. 1996;71(1):6-12. doi: 10.1046/j.1423-0410.1996.7110006.x.