PMID- 8839430
OWN - NLM
STAT- MEDLINE
DCOM- 19961204
LR  - 20190822
IS  - 0385-5600 (Print)
IS  - 0385-5600 (Linking)
VI  - 40
IP  - 6
DP  - 1996
TI  - Differential regulation of HLA-DR expression and antigen presentation in 
      Toxoplasma gondii-infected melanoma cells by interleukin 6 and interferon gamma.
PG  - 443-9
AB  - CD4+ cytotoxic T lymphocytes (CTL) clones, YT-4 and YT-9, specific for Toxoplasma 
      gondii (T. gondii)-infected melanoma SK-MEL 28 (P36), were generated from the 
      peripheral blood lymphocytes (PBL) of a patient with chronic toxoplasmosis. These 
      CTL clones were shown to secrete significant amounts of interleukin 6 (IL-6) and 
      interferon gamma (IFN-gamma) upon antigen (Ag)-specific stimulation. 
      Downregulation of human leukocyte antigen (HLA)-DR surface expression and HLA-DR 
      mRNA levels in P36 cells were observed when P36 cells were infected with T. 
      gondii. Such downregulated HLA-DR expressions of T. gondii-infected P36 cells 
      were upregulated by treatment with both recombinant IL-6 (rIL-6) and recombinant 
      IFN-gamma (rIFN-gamma). The antigen-presenting ability of T. gondii-infected P36 
      cells to T. gondii-infected cell-specific CTL was enhanced by rIFN-gamma but not 
      by rIL-6. The present study reveals the existence of differential regulation of 
      HLA-DR expression and Ag presentation in T. gondii-infected melanoma cells by 
      IL-6 and IFN-gamma.
FAU - Yang, T H
AU  - Yang TH
AD  - Department of Medical Zoology, Nagasaki University School of Medicine, Japan.
FAU - Aosai, F
AU  - Aosai F
FAU - Norose, K
AU  - Norose K
FAU - Ueda, M
AU  - Ueda M
FAU - Yano, A
AU  - Yano A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 0 (Cytokines)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Interleukin-6)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - CD4-Positive T-Lymphocytes/cytology/*immunology
MH  - Clone Cells
MH  - Cytokines/immunology
MH  - HLA-DR Antigens/*immunology
MH  - Humans
MH  - Interferon-gamma/*immunology
MH  - Interleukin-6/*immunology
MH  - Melanoma
MH  - T-Lymphocytes, Cytotoxic/cytology/*immunology
MH  - Toxoplasma/*immunology
MH  - Toxoplasmosis/blood/*immunology
MH  - Tumor Cells, Cultured
MH  - Up-Regulation
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1111/j.1348-0421.1996.tb01091.x [doi]
PST - ppublish
SO  - Microbiol Immunol. 1996;40(6):443-9. doi: 10.1111/j.1348-0421.1996.tb01091.x.