PMID- 8839887
OWN - NLM
STAT- MEDLINE
DCOM- 19961209
LR  - 20190816
IS  - 0003-3995 (Print)
IS  - 0003-3995 (Linking)
VI  - 39
IP  - 3
DP  - 1996
TI  - Translocation t(10;11) involving the MLL gene in acute myeloid leukemia. 
      Importance of fluorescence in situ hybridization (FISH) analysis.
PG  - 147-51
AB  - Fluorescence in situ hybridization analysis in an infant with acute monocytic 
      leukemia revealed a complex translocation, t(10;11;4) (p12; q23;q26). Southern 
      blot analysis confirmed the existence of rearrangement of the MLL gene. The 
      frequent occurrence of complex translocations involving 10p12 and 11q23 is 
      discussed in function of the opposite orientation of the AF10 and MLL genes on 
      10p and 11q. The importance of FISH analysis in t(10; 11) is emphasized.
FAU - Berger, R
AU  - Berger R
AD  - Unite INSERM U 301, Institut de Genetique Moleculaire, Paris, France.
FAU - Le Coniat, M
AU  - Le Coniat M
FAU - Flexor, M A
AU  - Flexor MA
FAU - Leblanc, T
AU  - Leblanc T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Ann Genet
JT  - Annales de genetique
JID - 0370562
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Chromosomes, Human, Pair 10/genetics/*ultrastructure
MH  - Chromosomes, Human, Pair 11/genetics/*ultrastructure
MH  - DNA-Binding Proteins/*genetics
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Leukemia, Monocytic, Acute/*genetics/pathology
MH  - Male
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - *Proto-Oncogenes
MH  - *Transcription Factors
MH  - *Translocation, Genetic
RF  - 39
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Genet. 1996;39(3):147-51.