PMID- 8840025
OWN - NLM
STAT- MEDLINE
DCOM- 19970114
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 40
IP  - 1
DP  - 1996 Aug
TI  - Chronic intracerebroventricular cocaine differentially affects prodynorphin gene 
      expression in rat hypothalamus and caudate-putamen.
PG  - 153-6
AB  - We investigated the effects of sustained administration of cocaine on the 
      regulation of prodynorphin gene expression in rat brain. Intracerebroventricular 
      (i.c.v.) infusion of cocaine hydrochloride (30 micrograms/day) for 7 days, by 
      means of osmotic minipumps, elicited a significant 35% decrease of prodynorphin 
      mRNA levels in rat hypothalamus and increase (22%) in caudate-putamen. At the 
      same time and in the same animals, no significant changes were detected in the 
      hippocampus or in the nucleus accumbens. These results indicate that continuously 
      infused cocaine is able to modulate expression of the prodynorphin gene in 
      opposite directions or has no effect on prodynorphin expression, depending on the 
      brain region analysed. Cocaine, as well as opiates, might activate specific 
      neuronal pathways, shared by different classes of drugs of abuse, involving, at 
      least in part, the endogenous opioid system.
FAU - Romualdi, P
AU  - Romualdi P
AD  - Department of Pharmacology, University of Bologna, Italy. 
      romualdi@biocfarm.unibo.it
FAU - Donatini, A
AU  - Donatini A
FAU - Izenwasser, S
AU  - Izenwasser S
FAU - Cox, B M
AU  - Cox BM
FAU - Ferri, S
AU  - Ferri S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Enkephalins)
RN  - 0 (Protein Precursors)
RN  - 0 (RNA, Messenger)
RN  - 93443-35-7 (preproenkephalin)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Caudate Nucleus/drug effects/*metabolism
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Cocaine/administration & dosage/*pharmacology
MH  - Enkephalins/*biosynthesis
MH  - Hypothalamus/drug effects/*metabolism
MH  - Infusions, Parenteral
MH  - Male
MH  - Protein Precursors/*biosynthesis
MH  - Putamen/drug effects/*metabolism
MH  - RNA, Messenger/analysis/biosynthesis
MH  - Rats
MH  - Rats, Inbred F344
MH  - Transcription, Genetic/*drug effects
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - S0169328X96000915 [pii]
AID - 10.1016/0169-328x(96)00091-5 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 1996 Aug;40(1):153-6. doi: 10.1016/0169-328x(96)00091-5.