PMID- 8840897
OWN - NLM
STAT- MEDLINE
DCOM- 19970117
LR  - 20191210
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 60
IP  - 2
DP  - 1996 Aug
TI  - IRI-514, a synthetic peptide analogue of thymopentin, reduces the behavioral 
      response to social stress in rats.
PG  - 397-401
AB  - Thymopentin, a synthetic pentapeptide (Arg-Lys-Asp-Val-Tyr) corresponding to 
      amino acids 32-36 of the thymic polypeptide thymopoietin, has been reported to 
      block adrenocorticotrope responses to stress. The purpose of the present study 
      was to explore potential antistress properties of a synthetic analogue of 
      thymopentin, IRI-514 (Ac-Arg-Pro-Asp-Phe-NH2) using a behavioral response to a 
      stressor. The behavioral response to social conflict stress (resident-intruder 
      paradigm) was evaluated by the elevated plus-maze test of anxiety in adult Wistar 
      rats. A single subcutaneous (SC) administration of IRI-514, 48 h before stress, 
      dose-dependently reversed the anxiety-like behavior induced by the social stress. 
      The effect of IRI-514 was present over an extended period (24-72 h) following SC 
      administration and was maximally effective at a dose of 1 mg/kg. These results 
      indicate that IRI-514 has a long-lasting modulatory effect on behavioral 
      responses to a stressor, and suggest that thymopoietin-derived peptides may have 
      a role in modulating both behavioral and neuroendocrine responses to stress.
FAU - Menzaghi, F
AU  - Menzaghi F
AD  - Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, 
      USA.
FAU - Heinrichs, S C
AU  - Heinrichs SC
FAU - Vargas-Cortes, M
AU  - Vargas-Cortes M
FAU - Goldstein, G
AU  - Goldstein G
FAU - Koob, G F
AU  - Koob GF
LA  - eng
GR  - AM 26741/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (IRI 514)
RN  - 0 (Immunologic Factors)
RN  - 0 (Oligopeptides)
RN  - O3Y80ZF13F (Thymopentin)
SB  - IM
MH  - Aggression/psychology
MH  - Animals
MH  - Anxiety/psychology
MH  - Behavior, Animal/*drug effects
MH  - Conflict, Psychological
MH  - Dose-Response Relationship, Drug
MH  - Exploratory Behavior/drug effects
MH  - Immunologic Factors/*pharmacology
MH  - Male
MH  - Oligopeptides/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - *Social Environment
MH  - Stress, Psychological/*physiopathology/psychology
MH  - Thymopentin/*analogs & derivatives/*pharmacology
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - S0031-9384(96)80010-2 [pii]
PST - ppublish
SO  - Physiol Behav. 1996 Aug;60(2):397-401.