PMID- 8841083
OWN - NLM
STAT- MEDLINE
DCOM- 19970110
LR  - 20180214
IS  - 0031-7012 (Print)
IS  - 0031-7012 (Linking)
VI  - 52
IP  - 4
DP  - 1996 Apr
TI  - Serotonin is involved in the ACTH-induced reversal of hemorrhagic shock in 
      anesthetized rats.
PG  - 207-15
AB  - In a rat model of volume-controlled hemorrhagic shock (mean arterial pressure = 
      20-24 mm Hg) causing the death of all saline-treated animals within 30 min, the 
      i.v. bolus injection of ACTH-(1-24) (160 micrograms/kg) produced an almost 
      complete and sustained reversal of the shock condition, with recovery of arterial 
      blood pressure, pulse pressure and respiratory rate, and with 100% survival at 
      the end of the experiment (2 h). The serotonin-depleting agent 
      p-chlorophenylalanine (316 mg/kg i.p., administered 66-70 h before hemorrhage) 
      almost completely prevented the effect of ACTH. The 5-HT1/5-HT2 receptor 
      antagonist, methysergide, prevented the effect of ACTH completely when injected 
      i.v. (5 mg/kg), but only in part when injected into a brain ventricle (i.c.v.) 
      (15 micrograms/rat); the 5-HT2 antagonist, ketanserin, prevented the effect of 
      ACTH completely when injected i.c.v. (1.5 micrograms/rat), but only in part when 
      injected i.v. (0.5 mg/kg); the 5-HT3 antagonist, MDL 72222, largely prevented the 
      effect of ACTH when injected i.c.v. (10 micrograms/rat), but had no influence at 
      all when injected i.v. (3 mg/kg); finally, the 5-HT4 antagonist, GR 125487, had 
      no effect when injected i.v. (5 micrograms/kg) or when injected i.c.v. (30 
      ng/rat). Overall, these data indicate that both CNS and peripheral serotonin play 
      an important role in the complex mechanism of the ACTH-induced hemorrhagic shock 
      reversal.
FAU - Bazzani, C
AU  - Bazzani C
AD  - Department of Biomedical Sciences, University of Modena, Italy.
FAU - Fiore, L
AU  - Fiore L
FAU - Ferrante, F
AU  - Ferrante F
FAU - Bertolini, A
AU  - Bertolini A
FAU - Guarini, S
AU  - Guarini S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Pharmacology
JT  - Pharmacology
JID - 0152016
RN  - 0 (Serotonin Agents)
RN  - 16960-16-0 (Cosyntropin)
RN  - 97F9DE4CT4 (Ketanserin)
RN  - R5J7E3L9SP (Fenclonine)
RN  - XZA9HY6Z98 (Methysergide)
SB  - IM
MH  - Animals
MH  - Cosyntropin/*therapeutic use
MH  - Female
MH  - Fenclonine/pharmacology
MH  - Ketanserin/pharmacology
MH  - Male
MH  - Methysergide/pharmacology
MH  - Rats
MH  - Serotonin Agents/*pharmacology
MH  - Shock, Hemorrhagic/*drug therapy
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1159/000139385 [doi]
PST - ppublish
SO  - Pharmacology. 1996 Apr;52(4):207-15. doi: 10.1159/000139385.