PMID- 8841845
OWN - NLM
STAT- MEDLINE
DCOM- 19961212
LR  - 20171206
IS  - 0391-3988 (Print)
IS  - 0391-3988 (Linking)
VI  - 19
IP  - 8
DP  - 1996 Aug
TI  - A cross-over study of a new low molecular weight heparin (Logiparin) in 
      hemodialysis.
PG  - 467-71
AB  - The safety and effectiveness of a low molecular weight heparin (LMWH) of 4500 +/- 
      1500 Daltons were evaluated in eight hemodialysis (HD) patients, in comparison 
      with unfractionated heparin (UFH). In phase A of the study 3000 +/- 500 
      anti-factor Xa (AFXa) IU of LMWH were administered in bolus for the three 
      consecutive HD sessions of a week. In phase B, 10000 +/- 2500 IU of UFH were 
      administered to the same patients for the same time. Were observed no significant 
      differences in hematocrit (Ht), platelets (Pt), fibronogen (FG) and prothrombin 
      time (PT). Whole blood activated coagulation time (WBACT) was more prolonged with 
      LMWH, 24 and 48 hours (start of next session) after administration (p < 0.05), 
      and less prolonged at 5, 60, 120, 180, 240 min compared to UFH (p < 0.001). The 
      activated partial thromboplastin time (APTT) and AFXa activity were more 
      prolonged with UFH at 60 and 240 min (p < 0.001). The clinical effectiveness of 
      the two preparations was similar as judged by thrombus formation and compression 
      time. In conclusion, the present study found no real differences between LMWH and 
      UFH, except for prolongation of WBACT 24 and 48 hours after the administration of 
      LWMH. This probably indicates a cumulative effect of the LMWH and needs further 
      investigation.
FAU - Koutsikos, D
AU  - Koutsikos D
AD  - Department of Nephrology, Aretaieon University Hospital, Athens-Greece.
FAU - Fourtounas, C
AU  - Fourtounas C
FAU - Kapetanaki, A
AU  - Kapetanaki A
FAU - Dalamanga, A
AU  - Dalamanga A
FAU - Tzanatos, H
AU  - Tzanatos H
FAU - Agroyannis, B
AU  - Agroyannis B
FAU - Kopelias, I
AU  - Kopelias I
FAU - Bosiolis, B
AU  - Bosiolis B
FAU - Rammos, G
AU  - Rammos G
FAU - Bovoleti, O
AU  - Bovoleti O
FAU - Sallum, G
AU  - Sallum G
FAU - Darema, M
AU  - Darema M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Int J Artif Organs
JT  - The International journal of artificial organs
JID - 7802649
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Logiparin)
RN  - 9001-26-7 (Prothrombin)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Adult
MH  - Blood Coagulation/*drug effects
MH  - Blood Platelets/cytology/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fibrinogen/metabolism
MH  - Hematocrit
MH  - Heparin, Low-Molecular-Weight/administration & dosage/*pharmacology
MH  - Humans
MH  - Kidney Failure, Chronic/*therapy
MH  - Male
MH  - Middle Aged
MH  - Molecular Weight
MH  - Partial Thromboplastin Time
MH  - Prothrombin/metabolism
MH  - Renal Dialysis/*adverse effects
MH  - Thrombosis/prevention & control
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
PST - ppublish
SO  - Int J Artif Organs. 1996 Aug;19(8):467-71.