PMID- 8843151
OWN - NLM
STAT- MEDLINE
DCOM- 19961205
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 394
IP  - 2
DP  - 1996 Sep 30
TI  - Expression of monocyte chemoattractant protein-1 mRNA and protein in cultured 
      human thyrocytes.
PG  - 137-40
AB  - Monocytes as well as lymphocytes infiltrate in the stroma of thyroid tissue in 
      autoimmune and destructive thyroiditis. Monocyte chemoattractant protein-1 
      (MCP-1) is a cytokine that attracts T-lymphocytes as well as monocytes. Using 
      human thyrocytes in primary cultures, we show that expression of MCP-1 mRNA and 
      protein is remarkably stimulated by both interleukin-1 (IL-1) and tumor necrosis 
      factor-alpha (TNF-alpha), and also that interferon-gamma (IFN-gamma) by itself is 
      a weak stimulant but has a synergistic activity with either IL-1 or TNF-alpha. 
      The finding indicates that MCP-1 can be produced by thyrocytes themselves, 
      suggesting a possible role of thyrocytes on accumulation of monocytes and 
      T-lymphocytes to the tissue from the blood in autoimmune and destructive 
      thyroiditis.
FAU - Kasai, K
AU  - Kasai K
AD  - Department of Endocrinology, Internal Medicine, Dokkyo University School of 
      Medicine, Mibu, Tochigi, Japan.
FAU - Banba, N
AU  - Banba N
FAU - Motohashi, S
AU  - Motohashi S
FAU - Hattori, Y
AU  - Hattori Y
FAU - Manaka, K
AU  - Manaka K
FAU - Shimoda, S I
AU  - Shimoda SI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA, Complementary)
RN  - 0 (Interleukin-1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 1CC1JFE158 (Dactinomycin)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9002-71-5 (Thyrotropin)
RN  - 9010-34-8 (Thyroglobulin)
RN  - 98600C0908 (Cycloheximide)
SB  - IM
MH  - Cells, Cultured
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Cycloheximide/pharmacology
MH  - DNA, Complementary
MH  - Dactinomycin/pharmacology
MH  - Dexamethasone/pharmacology
MH  - Electrophoresis, Agar Gel
MH  - Graves Disease/*metabolism
MH  - Humans
MH  - Interferon-gamma/pharmacology
MH  - Interleukin-1/pharmacology
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Thyroglobulin/metabolism
MH  - Thyroid Gland/cytology/*metabolism/pathology
MH  - Thyrotropin/pharmacology
MH  - Tumor Necrosis Factor-alpha/pharmacology
MH  - Up-Regulation/physiology
EDAT- 1996/09/30 00:00
MHDA- 1996/09/30 00:01
CRDT- 1996/09/30 00:00
PHST- 1996/09/30 00:00 [pubmed]
PHST- 1996/09/30 00:01 [medline]
PHST- 1996/09/30 00:00 [entrez]
AID - 0014-5793(96)00935-0 [pii]
AID - 10.1016/0014-5793(96)00935-0 [doi]
PST - ppublish
SO  - FEBS Lett. 1996 Sep 30;394(2):137-40. doi: 10.1016/0014-5793(96)00935-0.