PMID- 8843235
OWN - NLM
STAT- MEDLINE
DCOM- 19961107
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 174
IP  - 4
DP  - 1996 Oct
TI  - Variation in the tumor necrosis factor-alpha gene promoter region may be 
      associated with death from meningococcal disease.
PG  - 878-80
AB  - Tumor necrosis factor-alpha (TNF-alpha) plays a central role in the 
      pathophysiology of sepsis. Levels of TNF-alpha are directly correlated with 
      severity in meningococcal disease (MD). A polymorphism in the promoter region of 
      the TNF-alpha gene is associated with differences in the secretion of TNF-alpha. 
      The TNF2 allele is associated with higher constitutive and inducible levels of 
      TNF-alpha secretion than is the TNF1 allele. To investigate whether possession of 
      the TNF2 allele is associated with severity in MD, the frequency of TNF1 and TNF2 
      alleles in 98 children with MD was compared. There were more deaths among 
      children who had the TNF2 allele (P = .03; relative risk [RR], 2.5; 95% 
      confidence interval [CI], 1.1-5.7) than in those who did not. There was also an 
      increased risk of severe disease in children with the TNF2 allele (P = .02; RR, 
      1.6; 95% CI, 1.1-2.3). Possession of the TNF2 allele predisposes to a worse 
      outcome in children with meningococcal infection.
FAU - Nadel, S
AU  - Nadel S
AD  - Department of Paediatrics, St Mary's Hospital Medical School, Imperial College, 
      London, United Kingdom.
FAU - Newport, M J
AU  - Newport MJ
FAU - Booy, R
AU  - Booy R
FAU - Levin, M
AU  - Levin M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Child
MH  - Humans
MH  - Meningococcal Infections/*genetics/mortality
MH  - *Promoter Regions, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
AID - 10.1093/infdis/174.4.878 [doi]
PST - ppublish
SO  - J Infect Dis. 1996 Oct;174(4):878-80. doi: 10.1093/infdis/174.4.878.