PMID- 884391
OWN - NLM
STAT- MEDLINE
DCOM- 19770922
LR  - 20220227
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 60
IP  - 1
DP  - 1977 May
TI  - The effect of delta9-tetrahydrocannabinol on body temperature and brain amine 
      concentrations in the rat at differnt ambient temperatures.
PG  - 65-71
AB  - 1. Rats were injected intravenously with 2 mg/kg 
      (-)-trans-delta9-tetrahydrocannabinol (delta9-THC) at ambient temperatures of 4 
      degrees, 21 degrees, 31 degrees and 37 degrees C. 2. The general behavior 
      exhibited by rats treated with delta9-THC was similar at all four ambient 
      temperatures. 3. Body temperatures were recorded continuously before and after 
      drug administration. At 4 degrees and 21 degrees C, delta9-THC caused hypothermia 
      whereas no change in body temperature occurred at 31 degrees and 37 degrees C. 4. 
      The concentrations in the whole brain of noradrenaline (NA), dopamine, 
      5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were 
      determined spectrophotofluorimetrically 1 h after drug administration. At 4 
      degrees C delta9-THC caused an increase of 5-HT, at 21 degrees C an increase of 
      5-HIAA, at 21 degrees C an increase of 5-HIAA AND A decrease of NA, and at 37 
      degrees C an increase of 5-HT and 5-HIAA. 5. At all ambient temperatures, 
      delta9-THC increased the brain levels of 5-HT and/or 5-HIAA. A correlation 
      between the delta9-THC-induced hypothermic response and the possible alteration 
      of brain 5-HT metabolism cannot be excluded.
FAU - Fennessy, M R
AU  - Fennessy MR
FAU - Taylor, D A
AU  - Taylor DA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Biogenic Amines)
RN  - 7J8897W37S (Dronabinol)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Biogenic Amines/*metabolism
MH  - Body Temperature/*drug effects
MH  - Brain Chemistry/*drug effects
MH  - Dronabinol/*pharmacology
MH  - Male
MH  - Rats
MH  - Temperature
MH  - Time Factors
PMC - PMC1667176
EDAT- 1977/05/01 00:00
MHDA- 1977/05/01 00:01
PMCR- 1978/05/01
CRDT- 1977/05/01 00:00
PHST- 1977/05/01 00:00 [pubmed]
PHST- 1977/05/01 00:01 [medline]
PHST- 1977/05/01 00:00 [entrez]
PHST- 1978/05/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.1977.tb16748.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 1977 May;60(1):65-71. doi: 10.1111/j.1476-5381.1977.tb16748.x.