PMID- 8844017
OWN - NLM
STAT- MEDLINE
DCOM- 19961231
LR  - 20071114
IS  - 0889-2229 (Print)
IS  - 0889-2229 (Linking)
VI  - 12
IP  - 12
DP  - 1996 Aug 10
TI  - HIV-specific cellular and humoral immune responses in primary HIV infection.
PG  - 1129-40
AB  - Primary human immunodeficiency virus (HIV) infection is characterized by a 
      high-titer viremia that declines precipitously within weeks, most likely as a 
      result of host immune responses. Peripheral blood mononuclear cells (PBMCs) and 
      plasma of four recently HIV-infected individuals were examined to assess the 
      humoral and cellular immune responses potentially involved in early suppression 
      of viral replication. Neutralizing antibodies against autologous viral isolates 
      were low or undetectable in three subjects studied. Cellular cytotoxicity was 
      assayed using Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell lines 
      (B-LCLs) infected with recombinant vaccinia that express HIV-1 proteins. HIV 
      envelope-specific cytotoxicity, which was not mediated by CD8+ cells nor human 
      leukocyte antigen (HLA) class I restricted, developed in PBMCs of all four 
      subjects early after primary infection, but was not correlated with declines in 
      viremia. Gag-specific cytotoxic T lymphocyte (CTL) activity was observed in 
      freshly isolated PBMCs of two subjects, and HIV-specific CTL cell lines were 
      cultured from PBMCs of three subjects shortly after HIV infection. 
      Antibody-dependent cellular cytotoxicity (ADCC) developed early in all four 
      subjects, and was temporally correlated with declines in viremia in two subjects 
      in whom viral load was well characterized. These data suggest that both CTL 
      responses and ADCC may be critical to control of viral replication in acute HIV 
      infection.
FAU - Connick, E
AU  - Connick E
AD  - Department of Medicine, University of Colorado Health Sciences Center, Denver 
      80220, USA.
FAU - Marr, D G
AU  - Marr DG
FAU - Zhang, X Q
AU  - Zhang XQ
FAU - Clark, S J
AU  - Clark SJ
FAU - Saag, M S
AU  - Saag MS
FAU - Schooley, R T
AU  - Schooley RT
FAU - Curiel, T J
AU  - Curiel TJ
LA  - eng
GR  - IT32 AI07447-01/AI/NIAID NIH HHS/United States
GR  - R01-CA37461/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/*immunology
MH  - Antibody Formation
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Female
MH  - HIV Infections/*immunology
MH  - HIV-1/*isolation & purification
MH  - Humans
MH  - *Immunity, Cellular
MH  - Male
EDAT- 1996/08/10 00:00
MHDA- 1996/08/10 00:01
CRDT- 1996/08/10 00:00
PHST- 1996/08/10 00:00 [pubmed]
PHST- 1996/08/10 00:01 [medline]
PHST- 1996/08/10 00:00 [entrez]
AID - 10.1089/aid.1996.12.1129 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1129-40. doi: 
      10.1089/aid.1996.12.1129.