PMID- 8844023
OWN - NLM
STAT- MEDLINE
DCOM- 19961231
LR  - 20041117
IS  - 0889-2229 (Print)
IS  - 0889-2229 (Linking)
VI  - 12
IP  - 12
DP  - 1996 Aug 10
TI  - Prevalence of HTLV type I infection in Iran: a serological and genetic study.
PG  - 1185-90
AB  - Several publications describe the presence of the human T cell lymphotropic virus 
      type I (HTLV-I) in Jewish individuals born in Mash-had, Iran. We report here the 
      results of HTLV-I serological and genetic studies in the non-Jewish population of 
      Mash-had as well as a neighboring area: Gonbad-Kavous. Seven hundred and seven 
      serum samples from Mash-had (694 healthy individuals and 13 patients with 
      lymphoma) and 90 from Gonbad-Kavous were tested for HTLV antibodies by gelatin 
      particle agglutination assay (PA) and confirmatory Western blots (WBs). 
      Seropositive rates of 3.0% (21 of 694) in Mash-had, 0% (0 of 90) in 
      Gonbad-Kavous, and 100% (13 of 13) in lymphoma cases were observed. HTLV-I DNA 
      sequence were amplified by polymerase chain reaction directly from the fresh 
      PBMCs of seropositive individuals. Phylogenetic analysis of the viral DNA 
      sequence indicated that the HTLV-I present in Mash-had belong to the HTLV-I 
      cosmopolitan clade. Altogether, these data indicate that Mash-had, located in 
      northeastern Iran, is a newly recognized endemic center for HTLV-I.
FAU - Safai, B
AU  - Safai B
AD  - Department of Dermatology, New York Medical College, Valhalla 10595, USA.
FAU - Huang, J L
AU  - Huang JL
FAU - Boeri, E
AU  - Boeri E
FAU - Farid, R
AU  - Farid R
FAU - Raafat, J
AU  - Raafat J
FAU - Schutzer, P
AU  - Schutzer P
FAU - Ahkami, R
AU  - Ahkami R
FAU - Franchini, G
AU  - Franchini G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - HTLV-I Infections/blood/*epidemiology/ethnology/genetics
MH  - Human T-lymphotropic virus 1/genetics/*isolation & purification
MH  - Humans
MH  - Iran
MH  - *Jews
MH  - Molecular Sequence Data
MH  - *Serologic Tests
EDAT- 1996/08/10 00:00
MHDA- 1996/08/10 00:01
CRDT- 1996/08/10 00:00
PHST- 1996/08/10 00:00 [pubmed]
PHST- 1996/08/10 00:01 [medline]
PHST- 1996/08/10 00:00 [entrez]
AID - 10.1089/aid.1996.12.1185 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1185-90. doi: 
      10.1089/aid.1996.12.1185.