PMID- 8844435
OWN - NLM
STAT- MEDLINE
DCOM- 19961219
LR  - 20221207
IS  - 0733-2459 (Print)
IS  - 0733-2459 (Linking)
VI  - 11
IP  - 2
DP  - 1996
TI  - Racial differences in the availability of human leukocyte antigen-matched 
      platelets.
PG  - 71-7
AB  - In view of the demonstrated difficulty of providing African American patients 
      with compatible red cells and bone marrow from the predominantly white donor 
      population in the United States, it should be determined if African American 
      patients have greater difficulty obtaining human leukocyte antigen (HLA)-matched 
      platelets. Twenty-two alloimmunized African American patients and 20 
      alloimmunized white patients were studied. These groups were HLA-matched against 
      our hospital pheresis service (1,157 donors), the local Red Cross pool (3,405 
      donors), and the combined population (4,562 donors). The frequency of each 
      patient's HLA phenotype was calculated in the white population and in the African 
      American population. More African Americans did not have a well matched (A or BU) 
      platelet donor. Fewer African American patients had sufficient matched (A and B) 
      donors to support the average period of aplasia. On average, the African American 
      patients had half as many matched donors as compared to the White patients. 
      Sixty-eight percent of African American patients had HLA types which were more 
      difficult to find in a white population. Ninety percent of white patients had HLA 
      phenotypes which were more common in the white population. We have shown that it 
      is more difficult to obtain HLA-matched platelets for alloimmunized African 
      American patients as compared to alloimmunized white patients. With Jarger donor 
      pools, platelet support for African American patients is easier, but uncommon HLA 
      types remain. Our results support efforts to enlarge the donor pool with an 
      emphasis on specific recruitment programs aimed at the African American 
      community.
FAU - King, K E
AU  - King KE
AD  - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland 21287, USA.
FAU - Ness, P M
AU  - Ness PM
FAU - Braine, H G
AU  - Braine HG
FAU - Armstrong, K S
AU  - Armstrong KS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Apher
JT  - Journal of clinical apheresis
JID - 8216305
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Black People
MH  - *Blood Donors
MH  - Blood Platelets/*immunology
MH  - Child
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - White People
EDAT- 1996/01/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1002/(SICI)1098-1101(1996)11:2<71::AID-JCA3>3.0.CO;2-7 [pii]
AID - 10.1002/(SICI)1098-1101(1996)11:2<71::AID-JCA3>3.0.CO;2-7 [doi]
PST - ppublish
SO  - J Clin Apher. 1996;11(2):71-7. doi: 
      10.1002/(SICI)1098-1101(1996)11:2<71::AID-JCA3>3.0.CO;2-7.