PMID- 8844976
OWN - NLM
STAT- MEDLINE
DCOM- 19961107
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 106
IP  - 2
DP  - 1996 Sep 10
TI  - Detection of human herpesvirus 6 sequences in lymphoma tissues by 
      immunohistochemistry and polymerase chain reactions.
PG  - 221-6
AB  - We have analyzed one Hodgkin's and six non-Hodgkin's lymphomas for the presence 
      of human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) DNA by polymerase 
      chain reaction (PCR) and antigens by immunohistochemistry. A large cell B-cell 
      lymphoma and a T-cell lymphoma were positive for HHV-6 antigens by 
      immunohistochemistry. Using PCR primers from the HHV-6 ZVH14 transforming DNA 
      segment, all seven tumors were positive. EBV DNA was not detected by PCR using 
      sequences from EBV internal repeat-3 region as primers. The data suggest an 
      etiologic involvement of HHV-6 in some human lymphomas. Although all seven of the 
      lymphoma tissues examined contained HHV-6 DNA, expression of HHV-6 antigens was 
      observed in only two cases, suggesting that expression of proteins was not 
      required for transformation.
FAU - Razzaque, A
AU  - Razzaque A
AD  - Division of Viral Products, Center for Biologics Evaluation and Research, FDA, 
      Rockville, MD 20852, USA.
FAU - Francillon, Y
AU  - Francillon Y
FAU - Jilly, P N
AU  - Jilly PN
FAU - Varricchio, F
AU  - Varricchio F
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - DNA, Viral/*analysis
MH  - Female
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphoma/*virology
MH  - Male
MH  - Middle Aged
MH  - *Polymerase Chain Reaction
EDAT- 1996/09/10 00:00
MHDA- 1996/09/10 00:01
CRDT- 1996/09/10 00:00
PHST- 1996/09/10 00:00 [pubmed]
PHST- 1996/09/10 00:01 [medline]
PHST- 1996/09/10 00:00 [entrez]
AID - 0304383596043297 [pii]
AID - 10.1016/0304-3835(96)04329-7 [doi]
PST - ppublish
SO  - Cancer Lett. 1996 Sep 10;106(2):221-6. doi: 10.1016/0304-3835(96)04329-7.