PMID- 8845008
OWN - NLM
STAT- MEDLINE
DCOM- 19961118
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 59
IP  - 15
DP  - 1996
TI  - Brain prostaglandins mediate the bombesin-induced increase in plasma levels of 
      catecholamines.
PG  - 1217-25
AB  - Intracerebroventricular (i.c.v.) administration of bombesin (0.1, 1.0, 10.0 
      nmol/animal) in urethane-anesthetized rats induced long-lasting and dose 
      dependent increases in plasma levels of adrenaline and noradrenaline. These 
      effects of bombesin were inhibited by i.c.v. pretreatment with indomethacin 
      (50-500 micrograms/animal), while the same dose of indomethacin by the 
      intravenous route was without effect. The bombesin-induced increases in plasma 
      levels of catecholamines were also inhibited by i.c.v. pretreatment with 
      diclofenac (100-500 micrograms/animal), a cyclooxygenase inhibitor other than 
      indomethacin. I.c.v. administration of thyrotropin releasing hormone (TRH) (10 
      nmol/animal) also induced increases in plasma levels of adrenaline and 
      noradrenaline, however, these increases were not modified by i.c.v. pretreatment 
      with indomethacin. The present results suggest that the bombesin-induced 
      increases in plasma levels of catecholamines are probably due to prostaglandins 
      synthetized in the brain with this neuropeptide. Furthermore, it is likely that 
      prostaglandins are not always involved in central activation of 
      sympatho-adrenomedullary system by other brain neuropeptides.
FAU - Okuma, Y
AU  - Okuma Y
AD  - Department of Pharmacology, Kochi Medical School, Japan.
FAU - Yokotani, K
AU  - Yokotani K
FAU - Osumi, Y
AU  - Osumi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Prostaglandins)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - PX9AZU7QPK (Bombesin)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - XXE1CET956 (Indomethacin)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Animals
MH  - Bombesin/administration & dosage/*pharmacology
MH  - Brain/drug effects/physiology
MH  - Diclofenac/pharmacology
MH  - Epinephrine/*blood
MH  - Indomethacin/pharmacology
MH  - Injections, Intraventricular
MH  - Kinetics
MH  - Male
MH  - Norepinephrine/*blood
MH  - Prostaglandins/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Thyrotropin-Releasing Hormone/pharmacology
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 0024320596004456 [pii]
AID - 10.1016/0024-3205(96)00445-6 [doi]
PST - ppublish
SO  - Life Sci. 1996;59(15):1217-25. doi: 10.1016/0024-3205(96)00445-6.