PMID- 8847287
OWN - NLM
STAT- MEDLINE
DCOM- 19961022
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 79
IP  - 6
DP  - 1995 Dec
TI  - Lung water measurement by nuclear magnetic resonance: correlation with 
      morphometry.
PG  - 2163-8
AB  - Estimates of lung water content obtained from nuclear magnetic resonance (NMR) 
      and morphometric and gravimetric measurements were compared in normal and 
      experimentally injured rats. Average lung water density (rho H2O) was measured by 
      an NMR technique in excised unperfused rat lungs (20 normal lungs and 12 lungs 
      with oleic acid-induced edema) at 0 (full passive deflation) and 30 cmH2O lung 
      inflation pressure and in vivo (4 normal rats and 8 rats with lung injury induced 
      by oleic acid or rapid saline infusion). The rho H2O values were compared with 
      morphometric measurements of lung tissue volume density (Vv) obtained from the 
      same lungs fixed at corresponding liquid-instillation pressures. A close 
      correlation was observed between rho H2O and Vv in normal and injured excised 
      lungs [correlation coefficient (r) = 0.910, P < 0.01]. In vivo rho H2O was also 
      closely correlated with Vv (r = 0.897, P < 0.01). The correlation coefficients 
      between rho H2O and gravimetric lung water content (LWGr) were lower in the 
      excised lung group (r = 0.663 and 0.692, respectively, for rho H2O at 0 and 30 
      cmH2O lung inflation pressure, P < 0.01) than in the in vivo study (r = 0.857, P 
      < 0.01). Our results indicate that NMR techniques, which are noninvasive and 
      nondestructive, provide reliable estimates of lung water density and that the 
      influence of lung inflation on rho H2O is important (compared with the effect of 
      lung water accumulation in lung injury) only in the presence of deliberately 
      induced very large variations in the lung inflation level.
FAU - Cutillo, A G
AU  - Cutillo AG
AD  - Department of Internal Medicine, University of Utah, Salt Lake City 84132, USA.
FAU - Goodrich, K C
AU  - Goodrich KC
FAU - Ganesan, K
AU  - Ganesan K
FAU - Watanabe, S
AU  - Watanabe S
FAU - Ailion, D C
AU  - Ailion DC
FAU - Albertine, K H
AU  - Albertine KH
FAU - Morris, A H
AU  - Morris AH
FAU - Durney, C H
AU  - Durney CH
LA  - eng
GR  - HL-31216/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
SB  - IM
MH  - Animals
MH  - Body Water/*metabolism
MH  - Female
MH  - Linear Models
MH  - Lung/*metabolism
MH  - Magnetic Resonance Spectroscopy
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1152/jappl.1995.79.6.2163 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1995 Dec;79(6):2163-8. doi: 10.1152/jappl.1995.79.6.2163.