PMID- 8849454
OWN - NLM
STAT- MEDLINE
DCOM- 19961122
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 274
IP  - 5287
DP  - 1996 Oct 25
TI  - Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.
PG  - 618-20
AB  - Human leukocyte antigen (HLA)-DM is a critical participant in antigen 
      presentation that catalyzes the release of class II-associated invariant 
      chain-derived peptides (CLIP) from newly synthesized class II histocompatibility 
      molecules, freeing the peptide-binding site for acquisition of antigenic 
      peptides. The mechanism for the selective release of CLIP but not other peptides 
      is unknown. DM was found to enhance the rate of peptide dissociation to an extent 
      directly proportional to the intrinsic rate of peptide dissociation from HLA-DR, 
      regardless of peptide sequence. Thus, CLIP is rapidly released in the presence of 
      DM, because its intrinsic rate of dissociation is relatively high. In antigen 
      presentation, DM has the potential to markedly enhance the rate of peptide 
      exchange, favoring the presentation of peptides with slower intrinsic rates of 
      dissociation.
FAU - Weber, D A
AU  - Weber DA
AD  - Department of Pathology and Laboratory Medicine, Emory University School of 
      Medicine, Atlanta, GA 30322, USA.
FAU - Evavold, B D
AU  - Evavold BD
FAU - Jensen, P E
AU  - Jensen PE
LA  - eng
GR  - AI30554/AI/NIAID NIH HHS/United States
GR  - AI33614/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (H2-M antigens)
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DM antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Peptides)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (invariant chain)
SB  - IM
CIN - Science. 1996 Oct 25;274(5287):526-7. PMID: 8928005
MH  - Amino Acid Sequence
MH  - Antigen Presentation
MH  - Antigens, Differentiation, B-Lymphocyte/*metabolism
MH  - Binding Sites
MH  - HLA-D Antigens/*metabolism
MH  - HLA-DR Antigens/immunology/*metabolism
MH  - Histocompatibility Antigens Class II/*metabolism
MH  - Humans
MH  - Kinetics
MH  - Molecular Sequence Data
MH  - Peptides/immunology/*metabolism
MH  - Recombinant Fusion Proteins/metabolism
EDAT- 1996/10/25 00:00
MHDA- 1996/10/25 00:01
CRDT- 1996/10/25 00:00
PHST- 1996/10/25 00:00 [pubmed]
PHST- 1996/10/25 00:01 [medline]
PHST- 1996/10/25 00:00 [entrez]
AID - 10.1126/science.274.5287.618 [doi]
PST - ppublish
SO  - Science. 1996 Oct 25;274(5287):618-20. doi: 10.1126/science.274.5287.618.