PMID- 8854212
OWN - NLM
STAT- MEDLINE
DCOM- 19961219
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 71
IP  - 3
DP  - 1996 Jul
TI  - Implication of ATP-sensitive K+ channels in various stress-induced analgesia 
      (SIA) in mice.
PG  - 269-72
AB  - Exposure to footshock (2 mA, 1-sec duration, 0.2 Hz for 15 min; FS), forced 
      swimming (water at 20 degrees C for 3 min, SW) or psychological stress (using a 
      communication box for 5 min, PSY) produced antinociceptive effects 
      (stress-induced analgesia, SIA). Intracerebroventricular (i.c.v.) injection of 
      glibenclamide (10-40 micrograms/mouse), an ATP-sensitive K+ (KATP) channel 
      blocker, antagonized FS-SIA, while SW- and PSY-SIA were unaffected by the 
      compound. Cromakalim (0.1-10 micrograms/mouse, i.c.v.), a KATP-channel opener, 
      did not affect FS-, SW- or PSY-SIA. Thus, we provided evidence that central KATP 
      channels participate in the production of FS-SIA but not production of SW- or 
      PSY-SIA; and we suggest that glibenclamide, through closing of KATP channels, 
      suppresses mu-opioid receptor functions, which subsequently leads to the 
      inhibition of FS-SIA since antinociception is produced by the activation of 
      mu-receptors.
FAU - Nakao, K
AU  - Nakao K
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki 
      University, Japan.
FAU - Takahashi, M
AU  - Takahashi M
FAU - Kaneto, H
AU  - Kaneto H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 0 (Benzopyrans)
RN  - 0 (Potassium Channels)
RN  - 0 (Pyrroles)
RN  - 0G4X367WA3 (Cromakalim)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - SX6K58TVWC (Glyburide)
SB  - IM
MH  - Adenosine Triphosphate/*pharmacology
MH  - *Analgesia
MH  - Animals
MH  - Benzopyrans/pharmacology
MH  - Cromakalim
MH  - Glyburide/pharmacology
MH  - Male
MH  - Mice
MH  - Potassium Channels/*physiology
MH  - Pyrroles/pharmacology
MH  - Stress, Physiological/*physiopathology
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
AID - 10.1254/jjp.71.269 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1996 Jul;71(3):269-72. doi: 10.1254/jjp.71.269.