PMID- 8854884
OWN - NLM
STAT- MEDLINE
DCOM- 19970218
LR  - 20190830
IS  - 0009-5915 (Print)
IS  - 0009-5915 (Linking)
VI  - 105
IP  - 4
DP  - 1996 Oct
TI  - Clustered organization and conservation of the Xiphophorus maculatus D locus, 
      which includes two distinct gene sequences.
PG  - 242-9
AB  - Genomic organization and chromosomal localization of a previously uncharacterized 
      D (Donor) locus in Xiphophorus and Poecilia species was investigated using 
      fluorescence in situ hybridization (FISH) and Southern blot analysis. Part of 
      this region is thought to be involved in the recombination event leading to 
      formation of the Xmrk oncogene and it has recently been shown that this locus 
      includes two different genes, one with high homology to a zinc finger protein of 
      the Kruppel type, and the other an unknown gene with high similarity to a 
      Caenorhabditis elegans gene. FISH to Xiphophorus chromosomes revealed that these 
      two unrelated genes are closely linked and clustered at a unique chromosomal 
      site. Southern blot hybridization patterns suggest that these genes exist in the 
      genome as multiple copies. Furthermore, similar genomic organization profiles 
      seem to prevail among other related fish. In particular, our FISH experiments 
      reveal the existence of a conserved homologous chromosomal segment harboring the 
      zinc finger protein sequence in several poeciliid fish.
FAU - Nanda, I
AU  - Nanda I
AD  - Department of Human Genetics, University of Wurzburg, Biocenter, Am Hubland, 
      D-97074 Wurzburg, Germany.
FAU - Weis, S
AU  - Weis S
FAU - Fornzler, D
AU  - Fornzler D
FAU - Altschmied, J
AU  - Altschmied J
FAU - Schartl, M
AU  - Schartl M
FAU - Schmid, M
AU  - Schmid M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - Chromosoma
JT  - Chromosoma
JID - 2985138R
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Southern
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - Cyprinodontiformes/*genetics
MH  - Evolution, Molecular
MH  - In Situ Hybridization
MH  - In Situ Hybridization, Fluorescence
MH  - Metaphase
MH  - Multigene Family/*genetics
MH  - Phylogeny
MH  - Poecilia/genetics
MH  - Zinc Fingers/*genetics
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
AID - 10.1007/BF02528773 [doi]
PST - ppublish
SO  - Chromosoma. 1996 Oct;105(4):242-9. doi: 10.1007/BF02528773.