PMID- 8855518
OWN - NLM
STAT- MEDLINE
DCOM- 19970107
LR  - 20220310
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 23
IP  - 4
DP  - 1996 Aug
TI  - Effect of methamphetamine on glutamate-positive neurons in the adult and 
      developing rat somatosensory cortex.
PG  - 328-34
AB  - The neurotoxic effects of methamphetamine (MA) on dopaminergic and serotonergic 
      terminals have been well-documented. Another neurotoxic effect of MA is neuronal 
      degeneration in the somatosensory cortex, as seen by silver staining. The 
      neurochemical characteristics of these degenerating neurons are unknown. Using 
      glutamate and glial fibrillary acid protein (GFAP) immunohistochemistry, it was 
      found that MA exposure in adult rats (10 mg/kg given 4 times intraperotoneally 
      (i.p.) at 2-h intervals) causes localized depletion of glutamate-positive neurons 
      and astrogliosis in the somatosensory cortex 3 days following treatment. The 
      affected region covered the middle one-third portion from the longitudinal 
      fissure to the rhinal sulcus and was predominately seen in layers II-III of the 
      cortex. This pattern of depletion is consistent with that demonstrated previously 
      with silver staining following MA, d-amphetamine, and 
      3,4-methylenedioxymethamphetmine (MDMA) exposures. Comparable efforts were not 
      found in developing animals at ages previously shown to also be resistant to 
      MA-induced effects on dopaminergic terminals (age 20 and 40 days). Results 
      suggest that MA exposure induces degeneration of glutamatergic neurons in the 
      somatosensory cortex of adult rats.
FAU - Pu, C
AU  - Pu C
AD  - Division of Developmental Biology, Children's Hospital Research Foundation, 
      Cincinnati, Ohio 45229, USA.
FAU - Broening, H W
AU  - Broening HW
FAU - Vorhees, C V
AU  - Vorhees CV
LA  - eng
GR  - DA06733/DA/NIDA NIH HHS/United States
GR  - ES06096/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Neurotoxins)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Animals
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Evaluation Studies as Topic
MH  - Glial Fibrillary Acidic Protein/analysis
MH  - Glutamic Acid/*analysis
MH  - Immunohistochemistry
MH  - Male
MH  - Methamphetamine/*pharmacology
MH  - Neurons/chemistry/*drug effects
MH  - Neurotoxins/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Somatosensory Cortex/chemistry/*drug effects/growth & development
EDAT- 1996/08/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.1002/(SICI)1098-2396(199608)23:4<328::AID-SYN11>3.0.CO;2-T [pii]
AID - 10.1002/(SICI)1098-2396(199608)23:4<328::AID-SYN11>3.0.CO;2-T [doi]
PST - ppublish
SO  - Synapse. 1996 Aug;23(4):328-34. doi: 
      10.1002/(SICI)1098-2396(199608)23:4<328::AID-SYN11>3.0.CO;2-T.