PMID- 8857665
OWN - NLM
STAT- MEDLINE
DCOM- 19961230
LR  - 20191024
IS  - 0893-5785 (Print)
IS  - 0893-5785 (Linking)
VI  - 9
IP  - 2
DP  - 1996 Apr
TI  - Chemical characterization of melanins in sheep wool and human hair.
PG  - 51-7
AB  - The color of hair and wool in mammals and feathers in birds is mostly determined 
      by the quantity and quality of melanins that are synthesized in follicular 
      melanocytes and transferred to keratinocytes. These are two chemically distinct 
      types of melanin pigments: the black to brown eumelanins and the yellow to 
      reddish pheomelanins. Melanins in sheep wool and human hair of various colors 
      were characterized by HPLC methods to estimate 5,6-dihydroxyindole-2-carboxylic 
      acid (DHICA)-derived units in eumelanins and benzothiazine units in pheomelanins. 
      Melanins were also characterized by spectrophotometric methods after differential 
      solubilization in alkalies. It was demonstrated that 1) black wool in Asiatic 
      sheep contains eumelanin with the DHICA content similar to black mouse melanin, 
      while black to brown melanins from human hair contain much lower ratios of 
      DHICA-derived units, comparable to the slaty mutation in mice, 2) dark brown to 
      brown hair in human contains eumelanin whose chemical properties are 
      indistinguishable from those of black hair; 3) dark red wool and red human hair 
      contain pheomelanic pigments whose chemical properties are rather different from 
      those of yellow pheomelanins in mice, and 4) light brown, blonde, and red hairs 
      in human can be differentiated from each other with this methodology.
FAU - Ozeki, H
AU  - Ozeki H
AD  - Fujita Health University School of Health Sciences, Aichi, Japan.
FAU - Ito, S
AU  - Ito S
FAU - Wakamatsu, K
AU  - Wakamatsu K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Pigment Cell Res
JT  - Pigment cell research
JID - 8800247
RN  - 0 (Indoles)
RN  - 0 (Melanins)
RN  - 0 (Thiazines)
RN  - 0 (pheomelanin)
RN  - 12627-86-0 (eumelanin)
RN  - 4790-08-3 (5,6-dihydroxy-2-indolylcarboxylic acid)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Hair/*chemistry
MH  - Hair Color
MH  - Humans
MH  - Indoles/analysis
MH  - Melanins/*analysis/chemistry
MH  - Mice
MH  - *Sheep
MH  - Solubility
MH  - Species Specificity
MH  - Spectrophotometry
MH  - Thiazines/analysis
EDAT- 1996/04/01 00:00
MHDA- 1996/04/01 00:01
CRDT- 1996/04/01 00:00
PHST- 1996/04/01 00:00 [pubmed]
PHST- 1996/04/01 00:01 [medline]
PHST- 1996/04/01 00:00 [entrez]
AID - 10.1111/j.1600-0749.1996.tb00088.x [doi]
PST - ppublish
SO  - Pigment Cell Res. 1996 Apr;9(2):51-7. doi: 10.1111/j.1600-0749.1996.tb00088.x.