PMID- 8858295
OWN - NLM
STAT- MEDLINE
DCOM- 19970325
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 308
IP  - 3
DP  - 1996 Jul 25
TI  - Antinociceptive effects of oral clonidine and S12813-4 in acute colon 
      inflammation in rats.
PG  - 251-9
AB  - Acute colonic inflammation was induced by perendoscopic injection of 50 
      microleters of dilute formalin (5%) in the depth of the colonic wall (c.w.) in 
      rats. Compared to saline injection, the procedure was followed by nociceptive 
      behaviors from which visceral nociception was quantified. The alpha 
      2-adrenoceptor agonist, clonidine 2-[2,6-dichlorophenylamine]-2-imidazole 
      hydrochloride (75, 150 and 300 mg/kg), administered orally 15 min after c.w. 
      injection of formalin significantly reduced the nociceptive responses at the high 
      dose only. However, when administered 30 min prior to nociceptive stimulation, 
      the compound exhibited an antinociceptive effect at the three doses. A novel 
      analgesic, the compound "S12813-4' 
      3-[2-(4-phenylpiperazine-1-yl)-ethyl]-2-oxo-2,3-dihydro-oxazolo[b] pyridine, 
      chlorydrate (10, 30 and 90 mg/kg), given orally displayed antinociceptive effects 
      whatever the administration schedule, before or after c.w. injection of formalin. 
      The antinociceptive effect of S12813-4 (30 mg/kg given orally) was prevented by 
      subcutaneous (s.c.) injection of yohimbine or idazoxan (1 mg/kg). We conclude 
      that visceral nociception elicited by formalin-induced colonic inflammation is 
      attenuated by clonidine and S12813-4. The pharmacological profiles of the two 
      compounds and the inhibition of the antinociceptive effect of S12813-4 by 
      yohimbine and idazoxan suggest that noradrenergic mechanisms are involved in the 
      transmission and/or modulation of the nociceptive influx arising from the 
      inflamed colon.
FAU - Miampamba, M
AU  - Miampamba M
AD  - Institut National de la Sante et de la Recherche Medicale, Hopital Edouard 
      Herriot, Lyon, France.
FAU - Chery-Croze, S
AU  - Chery-Croze S
FAU - Detolle-Sarbach, S
AU  - Detolle-Sarbach S
FAU - Guez, D
AU  - Guez D
FAU - Chayvialle, J A
AU  - Chayvialle JA
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Analgesics)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Oxazoles)
RN  - 134336-97-3 (S 12813)
RN  - 1HG84L3525 (Formaldehyde)
RN  - 2Y49VWD90Q (Yohimbine)
RN  - MN3L5RMN02 (Clonidine)
RN  - Y310PA316B (Idazoxan)
SB  - IM
MH  - Acute Disease
MH  - Analgesics/*therapeutic use
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Clonidine/antagonists & inhibitors/*therapeutic use
MH  - Colitis/chemically induced/*drug therapy
MH  - Female
MH  - Formaldehyde/toxicity
MH  - Idazoxan/pharmacology
MH  - Oxazoles/antagonists & inhibitors/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Yohimbine/pharmacology
EDAT- 1996/07/25 00:00
MHDA- 1996/07/25 00:01
CRDT- 1996/07/25 00:00
PHST- 1996/07/25 00:00 [pubmed]
PHST- 1996/07/25 00:01 [medline]
PHST- 1996/07/25 00:00 [entrez]
AID - 0014299996003068 [pii]
AID - 10.1016/0014-2999(96)00306-8 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1996 Jul 25;308(3):251-9. doi: 10.1016/0014-2999(96)00306-8.