PMID- 8860097
OWN - NLM
STAT- MEDLINE
DCOM- 19970529
LR  - 20220330
IS  - 0803-7051 (Print)
IS  - 0803-7051 (Linking)
VI  - 5
IP  - 2
DP  - 1996 Mar
TI  - Adverse effects on risk of ischaemic heart disease of adding sugar to hot 
      beverages in hypertensives using diuretics. A six year follow-up in the 
      Copenhagen Male Study.
PG  - 91-7
AB  - Non insulin dependent diabetes mellitus (NIDDM) and essential hypertension (EH) 
      are two of several manifestations of the insulin resistance syndrome. Although 
      subjects with NIDDM and subjects with EH share a common defect in carbohydrate 
      metabolism, only diabetics are advised to avoid sugar. We tested the theory that 
      an adverse effect of diuretics treatment in men with EH with respect to risk of 
      ischaemic heart disease (IHD) would depend on the intake of dietary sugar using 
      sugar in hot beverages as a marker. The cohort consisted of 2,899 men from the 
      Copenhagen Male Study aged 53-74 years (mean 63) who were without overt 
      cardiovascular disease. Potential confounders were: age, alcohol,smoking, 
      physical activity, body mass index, blood pressure, fasting lipids, cotinine, 
      NIDDM,and social class. A total of 340 men took antihypertensives; 211 took 
      diuretics (95% thiazides and related agents), and 129 used other 
      antihypertensives. During 6 years, 179 men (6.2%) had a first IHD event. Among 
      the 340 men taking antihypertensives, the incidence rate was 11%. Diuretics use 
      was associated with a high risk of IHD in hypertensive men with a relatively high 
      intake of dietary sugar; the cumulative incidence rate was 22%; in diuretics 
      treated men with a low intake of sugar, the rate was 7%. After controlling for 
      potential confounders, relative risk (95% ci.) was 3.1(1.3-7.6), p = 001. Among 
      the 129 men who took other forms of antihypertensive drugs, the IHD incidence 
      rate was 8%, and independent of the intake of sugar. The results indicate that 
      the risk of IHD in hypertensives using diuretics is associated with intake of 
      dietary sugar, which may explain at least some of the discouraging effects of 
      antihypertensive agents on the reduction of risk of IHD.
FAU - Suadicani, P
AU  - Suadicani P
AD  - Epidemiological Research Unit, Clinic of Occupational Medicine, Righospitalet, 
      State University Hospital, Copenhagen, Denmark.
FAU - Hein, H O
AU  - Hein HO
FAU - Gyntelberg, F
AU  - Gyntelberg F
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Blood Press
JT  - Blood pressure
JID - 9301454
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Coffee)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Diuretics)
RN  - 0 (Tea)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antihypertensive Agents/therapeutic use
MH  - *Coffee
MH  - Denmark/epidemiology
MH  - Dietary Sucrose/*adverse effects
MH  - Diuretics/*therapeutic use
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypertension/complications/*drug therapy
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/epidemiology/*etiology
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Risk Factors
MH  - *Tea
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.3109/08037059609062114 [doi]
PST - ppublish
SO  - Blood Press. 1996 Mar;5(2):91-7. doi: 10.3109/08037059609062114.