PMID- 8861907
OWN - NLM
STAT- MEDLINE
DCOM- 19961216
LR  - 20220228
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 87
IP  - 2
DP  - 1996 Oct 18
TI  - Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of 
      microfilament dynamics.
PG  - 227-39
AB  - Drosophila Enabled is required for proper formation of axonal structures and is 
      genetically implicated in signaling pathways mediated by Drosophila AbI. We have 
      identified two murine proteins, Mena and Evl, that are highly related to Enabled 
      as well as VASP (Vasodilator-Stimulated Phosphoprotein). A conserved domain 
      targets Mena to localized proteins containing a specific proline-rich motif. The 
      association of Mena with the surface of the intracellular pathogen Listeria 
      monocytogenes and the G-actin binding protein profilin suggests that this 
      molecule may participate in bacterial movement by facilitating actin 
      polymerization. Expression of neural-enriched isoforms of Mena in fibroblasts 
      induces the formation of abnormal F-actin-rich outgrowths, supporting a role for 
      this protein in microfilament assembly and cell motility.
FAU - Gertler, F B
AU  - Gertler FB
AD  - Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, 
      Washington 98104, USA.
FAU - Niebuhr, K
AU  - Niebuhr K
FAU - Reinhard, M
AU  - Reinhard M
FAU - Wehland, J
AU  - Wehland J
FAU - Soriano, P
AU  - Soriano P
LA  - eng
SI  - GENBANK/U72519
SI  - GENBANK/U72520
SI  - GENBANK/U72521
SI  - GENBANK/U72522
SI  - GENBANK/U72523
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Actins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Contractile Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (ENA-VASP proteins)
RN  - 0 (Enah protein, mouse)
RN  - 0 (Evl protein, mouse)
RN  - 0 (Ligands)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Pfn1 protein, mouse)
RN  - 0 (Phosphoproteins)
RN  - 0 (Profilins)
RN  - 0 (Proteins)
RN  - 0 (vasodilator-stimulated phosphoprotein)
SB  - IM
MH  - Actin Cytoskeleton/*physiology/ultrastructure
MH  - Actins/physiology
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/*physiology
MH  - Cell Adhesion Molecules/*physiology
MH  - *Contractile Proteins
MH  - *Cytoskeletal Proteins
MH  - DNA-Binding Proteins/*physiology
MH  - Fluorescent Antibody Technique, Indirect
MH  - Ligands
MH  - Listeria monocytogenes/ultrastructure
MH  - Mice
MH  - Microfilament Proteins/metabolism
MH  - Molecular Sequence Data
MH  - Phosphoproteins/*physiology
MH  - Phosphorylation
MH  - Profilins
MH  - Proteins/*physiology
MH  - Rats
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - src Homology Domains
EDAT- 1996/10/18 00:00
MHDA- 1996/10/18 00:01
CRDT- 1996/10/18 00:00
PHST- 1996/10/18 00:00 [pubmed]
PHST- 1996/10/18 00:01 [medline]
PHST- 1996/10/18 00:00 [entrez]
AID - S0092-8674(00)81341-0 [pii]
AID - 10.1016/s0092-8674(00)81341-0 [doi]
PST - ppublish
SO  - Cell. 1996 Oct 18;87(2):227-39. doi: 10.1016/s0092-8674(00)81341-0.