PMID- 8862293
OWN - NLM
STAT- MEDLINE
DCOM- 19961113
LR  - 20220310
IS  - 0161-5505 (Print)
IS  - 0161-5505 (Linking)
VI  - 37
IP  - 10
DP  - 1996 Oct
TI  - SPECT and MRI evaluations of the posterior circulation in moyamoya disease.
PG  - 1613-7
AB  - We evaluated the posterior circulation in patients with moyamoya disease by SPECT 
      and MRI. METHODS: Six patients with idiopathic moyamoya disease were studied by 
      SPECT, MRI and angiography. Patients received an injection of 555-740 MBq of 
      99mTc-HMPAO, after which SPECT images were taken. The cerebral-to-cerebellar 
      activity ratio in five cerebral regions was calculated to assess the regional 
      cerebral blood flow (rCBF). The SPECT and MRI findings were then compared with 
      angiographic. RESULTS: Of the 12 posterior cerebral arteries (PCAs) in the six 
      patients studied, seven PCAs (58%) in five patients had a stenotic or occluded 
      lesion. Furthermore, rCBF in all five regions significantly decreased as the 
      degree of steno-occlusive lesions of the PCA progressed. No significant 
      correlation, however, was found between the steno-occlusive lesions of the 
      internal carotid artery bifurcation and the rCBF. The rCBF significantly 
      decreased in the absence of leptomeningeal collateral vessels from the PCA to the 
      anterior circulation. On the basis of the MR images, the frequency of cerebral 
      infractions significantly increased in patients with steno-occulasive PCA 
      lesions. CONCLUSION: The rCBF in moyamoya disease decreases proportionally with 
      the degree of steno-occlusive lesions of the PCA. The steno-occlusive PCA lesions 
      decrease the number of leptomeningeal collateral vessels to the anterior 
      circulation, thereby causing severe cerebral ischemia that is likely to result in 
      infractions.
FAU - Yamada, I
AU  - Yamada I
AD  - Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental 
      University, Japan.
FAU - Murata, Y
AU  - Murata Y
FAU - Umehara, I
AU  - Umehara I
FAU - Suzuki, S
AU  - Suzuki S
FAU - Matsushima, Y
AU  - Matsushima Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nucl Med
JT  - Journal of nuclear medicine : official publication, Society of Nuclear Medicine
JID - 0217410
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (Oximes)
RN  - 3B744AG22N (Technetium Tc 99m Exametazime)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Carotid Artery, Internal
MH  - Carotid Stenosis/diagnostic imaging/physiopathology
MH  - Cerebral Angiography
MH  - Cerebral Infarction/diagnosis
MH  - *Cerebrovascular Circulation
MH  - Child
MH  - Collateral Circulation
MH  - Constriction, Pathologic
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Moyamoya Disease/diagnosis/diagnostic imaging/*physiopathology
MH  - Organotechnetium Compounds
MH  - Oximes
MH  - Technetium Tc 99m Exametazime
MH  - *Tomography, Emission-Computed, Single-Photon
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
PST - ppublish
SO  - J Nucl Med. 1996 Oct;37(10):1613-7.