PMID- 886469
OWN - NLM
STAT- MEDLINE
DCOM- 19770922
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 202
IP  - 2
DP  - 1977 Aug
TI  - Leakage of dl-propranolol from cerebrospinal fluid to the bloodstream in the 
      rabbit.
PG  - 320-5
AB  - Intracerebroventricular (i.c.v.) injection of 500 microgram of dl-propranolol in 
      the conscious rabbit in a rise in mean arterial pressure followed by a small but 
      significant fall (3.2 +/- 1.4 mm Hg between 2 and 4 hours after injection), as 
      has been observed by others. The same dose injected i.v. resulted in a lowering 
      of mean arterial pressure of 6.0 +/- 2.4 mm Hg between 2 and 4 hours after 
      injection. After i.c.v. injection there was a rapid rise in plasma propranolol 
      concentration. Ten minutes after i.c.v. injection the concentration of 80% of the 
      level reached after giving the same dose i.v. After i.c.v. injection there was 
      significant blockade of cardiac beta adrenoreceptors for at least 2 hours. This 
      blockade was determined from the degree of attenuation of isoproterenol-induced 
      tachycardia in rabbits subjected to presynaptic sympathetic nerve block with 
      guanethidine and to vagal block with methscopolamine. Because of the rapid 
      leakage of propranolol from cerebrospinal fluid to plasma it is not possible by 
      means of the technique of i.c.v. injection of the drug to differentiate between 
      central nervous and systemic mechanisms contributing to the lowering of blood 
      pressure.
FAU - Anderson, W P
AU  - Anderson WP
FAU - Korner, P I
AU  - Korner PI
FAU - Bobik, A
AU  - Bobik A
FAU - Chalmers, J P
AU  - Chalmers JP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Heart Rate/drug effects
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Isoproterenol/antagonists & inhibitors/pharmacology
MH  - Male
MH  - Propranolol/*administration & dosage/blood/*cerebrospinal fluid/pharmacology
MH  - Rabbits
MH  - Time Factors
EDAT- 1977/08/01 00:00
MHDA- 1977/08/01 00:01
CRDT- 1977/08/01 00:00
PHST- 1977/08/01 00:00 [pubmed]
PHST- 1977/08/01 00:01 [medline]
PHST- 1977/08/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1977 Aug;202(2):320-5.