PMID- 8864887
OWN - NLM
STAT- MEDLINE
DCOM- 19970123
LR  - 20190116
IS  - 0021-9304 (Print)
IS  - 0021-9304 (Linking)
VI  - 33
IP  - 3
DP  - 1996 Fall
TI  - Different effects of phagocytosable particles during bone formation versus 
      remodeling.
PG  - 153-8
AB  - Previously, small phagocytosable particles of high density polyethylene (HDPE) 
      but not Ti6-Al4-V alloy, at a concentration of 10(8) particles/mL inhibited net 
      bone formation in vivo after 3 weeks in the bone harvest chamber (BHC). These 
      findings reflected the effects of particles during the phase of bone ingrowth. In 
      this study, we tested whether these effects persisted or were different during 
      the phase of bone maturation and remodeling. BHCs were bilaterally implanted in 
      mature male NZW rabbits. After a 6-week period for osseointegration, the contents 
      of the chamber were harvested and discarded. One percent sodium hyaluronate, the 
      carrier, was then placed within the canal of the chambers bilaterally and the 
      tissue within the chambers was harvested 3 weeks later. HDPE particles were then 
      inserted unilaterally for a 3-week period, followed by Ti6-Al4-V for 3 weeks, 
      HDPE for 6 weeks, and Ti6-Al4-V for 6 weeks. The side chosen for each treatment 
      was switched consecutively; the nonimplanted, contralateral chamber served as a 
      control. At 3 weeks the control treatments yielded trabeculae of woven bone in a 
      fibrovascular stroma. By 6 weeks, the peripheral trabeculae were thicker, and a 
      central marrow cavity was developing. Bone ingrowth was less with HDPE particles 
      at 3 and 6 weeks compared to controls. Ti6-Al4-V particles did not inhibit bone 
      ingrowth at 3 weeks but showed a trend at 6 weeks. The characteristics of 
      particles affect the differentiation, maturation, and remodeling of mesenchymal 
      tissue differently.
FAU - Goodman, S
AU  - Goodman S
AD  - Division of Orthopaedic Surgery, Stanford University Medical Center, CA 94305, 
      USA.
FAU - Aspenberg, P
AU  - Aspenberg P
FAU - Song, Y
AU  - Song Y
FAU - Regula, D
AU  - Regula D
FAU - Lidgren, L
AU  - Lidgren L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomed Mater Res
JT  - Journal of biomedical materials research
JID - 0112726
RN  - 0 (Alloys)
RN  - 0 (Polyethylenes)
RN  - 12743-70-3 (titanium alloy (TiAl6V4))
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - *Alloys
MH  - Animals
MH  - Bone Development/*physiology
MH  - Bone Marrow Cells
MH  - Bone Remodeling/*physiology
MH  - Bone and Bones/cytology/metabolism
MH  - Cell Differentiation/physiology
MH  - Hyaluronic Acid/metabolism
MH  - Macrophages/physiology
MH  - Male
MH  - Particle Size
MH  - Phagocytosis/*physiology
MH  - *Polyethylenes
MH  - Rabbits
MH  - *Titanium
EDAT- 1996/01/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1002/(SICI)1097-4636(199623)33:3<153::AID-JBM5>3.0.CO;2-P [pii]
AID - 10.1002/(SICI)1097-4636(199623)33:3<153::AID-JBM5>3.0.CO;2-P [doi]
PST - ppublish
SO  - J Biomed Mater Res. 1996 Fall;33(3):153-8. doi: 
      10.1002/(SICI)1097-4636(199623)33:3<153::AID-JBM5>3.0.CO;2-P.