PMID- 8865218
OWN - NLM
STAT- MEDLINE
DCOM- 19970115
LR  - 20190726
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 19
IP  - 8
DP  - 1996 Aug
TI  - Electrostimulated cardiomyoplasty: from experimental to clinical studies.
PG  - 1205-10
AB  - Cardiomyoplasty is a method for managing patients with dilated cardiomyopathy. We 
      evaluated the means of carbon fiber electrode stimulation of the nerve to the 
      latissimus dorsi muscle (LDM) in dogs to increase skeletal muscle contractility. 
      Histochemical examination of biopsies of muscle electrically conditioned by a 
      single pulse stimulator via the thoracodorsal nerve demonstrated transformation 
      of muscle into fatigue resistant slow fibers without damage to muscle or nerve 
      tissue. Canine experiments confirmed that carbon fibers are one of the best 
      electrodes for chronic LDM stimulation. Between 1988 and 1992, we operated on ten 
      patients, New York Heart Association (NYHA) Class III (4 patients) and Class IV 
      (6 patients), with a mean left ventricular ejection fraction (LVEF) of 23%. The 
      indications for cardiomyoplasty were idiopathic (7 patients) and ischemic (3 
      patients) cardiomyopathy refractory to maximum medical therapy. The operative 
      procedure was performed via median sternotomy (5 patients) and left thoracotomy 
      (5 patients). There was one operative mortality and two additional deaths during 
      the late follow-up period. The mean postoperative LVEF increased to 27%. 
      Functional class, quality-of-life, and ventricular performance were improved 
      after cardiomyoplasty. Two of the surviving patients are in NYHA Class I, four in 
      Class II, and one in Class III.
FAU - Dumcius, A
AU  - Dumcius A
AD  - Laboratory of Cardiovascular Surgery, Institute for Biomedical Research, Kaunas, 
      Lithuania.
FAU - Salcius, K
AU  - Salcius K
FAU - Raliene, L
AU  - Raliene L
FAU - Vaskelyte, J
AU  - Vaskelyte J
FAU - Giedraitis, S
AU  - Giedraitis S
FAU - Sirvinskas, E
AU  - Sirvinskas E
FAU - Marcinkeviciene, J
AU  - Marcinkeviciene J
FAU - Skucas, J
AU  - Skucas J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
CIN - Pacing Clin Electrophysiol. 1997 May;20(5 Pt 1):1380-1. PMID: 9170144
MH  - Animals
MH  - Cardiomyopathies/physiopathology/*surgery
MH  - *Cardiomyoplasty/methods
MH  - Dogs
MH  - Echocardiography
MH  - Electric Stimulation
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Postoperative Complications
MH  - Sternum/surgery
MH  - Stroke Volume
MH  - Thoracotomy
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.1111/j.1540-8159.1996.tb04190.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 1996 Aug;19(8):1205-10. doi: 
      10.1111/j.1540-8159.1996.tb04190.x.