PMID- 8865964
OWN - NLM
STAT- MEDLINE
DCOM- 19970206
LR  - 20190826
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 20
IP  - 5
DP  - 1996 Aug
TI  - Differential effects of ethanol on feline rage and predatory attack behavior: an 
      underlying neural mechanism.
PG  - 882-9
AB  - Previous studies have shown that, at certain dose levels, ethanol can exert a 
      powerful, facilitatory effect on aggressive behavior in both animals and humans. 
      In the cat, however, it was discovered that ethanol differentially alters two 
      forms of aggression that are common to this species. Defensive rage behavior is 
      significantly enhanced, whereas predatory attack behavior is suppressed by 
      ethanol administration. One possible mechanism governing alcohol's potentiation 
      of defensive rage behavior is that it acts on the descending pathway from the 
      medial hypothalamus to the midbrain periaqueductal gray (PAG)-an essential 
      pathway for the expression of defensive rage behavior that uses excitatory amino 
      acids as a neurotransmitter. This hypothesis is supported by the finding that the 
      excitatory effects of alcohol on defensive rage behavior are blocked by 
      administration of the N-methyl-D-aspartate antagonist 
      alpha-2-amino-7-phosphoheptanoic acid (AP-7) when microinjected into the 
      periaqueductal gray, a primary neuronal target of descending fibers from the 
      medial hypothalamus that mediate the expression of defensive rage behavior. Thus, 
      the present study establishes for the first time a specific component of the 
      neural circuit for defensive rage behavior over which the potentiating effects of 
      ethanol are mediated.
FAU - Schubert, K
AU  - Schubert K
AD  - Department of Neurosciences, New Jersey Medical School, UMDNJ, Newark, USA.
FAU - Shaikh, M B
AU  - Shaikh MB
FAU - Han, Y
AU  - Han Y
FAU - Poherecky, L
AU  - Poherecky L
FAU - Siegel, A
AU  - Siegel A
LA  - eng
GR  - NS07941-25/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Aggression/*drug effects/physiology
MH  - Animals
MH  - Brain Mapping
MH  - Cats
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/pharmacokinetics/*pharmacology
MH  - Female
MH  - Hypothalamus, Middle/*drug effects/physiology
MH  - Male
MH  - Nerve Net/drug effects/physiology
MH  - Neural Pathways/drug effects/physiology
MH  - Periaqueductal Gray/*drug effects/physiology
MH  - Predatory Behavior/*drug effects/physiology
MH  - Rage/*drug effects/physiology
MH  - Receptors, N-Methyl-D-Aspartate/drug effects/physiology
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.1111/j.1530-0277.1996.tb05267.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 1996 Aug;20(5):882-9. doi: 
      10.1111/j.1530-0277.1996.tb05267.x.