PMID- 8866229
OWN - NLM
STAT- MEDLINE
DCOM- 19970203
LR  - 20191101
IS  - 1052-9551 (Print)
IS  - 1052-9551 (Linking)
VI  - 5
IP  - 3
DP  - 1996 Sep
TI  - Presence of human herpesvirus type 6 in sporadic lymphoproliferative disorders. A 
      comparative study.
PG  - 166-72
AB  - A supportive or causal role for human herpesvirus 6 (HHV-6) in 
      lymphoproliferative disorders is still controversial. Different results were 
      obtained in both tissue-based and serological investigations. We investigated 243 
      lymph node and salivary gland tissue biopsies for the presence of viral DNA by 
      using a newly developed, highly sensitive nested polymerase chain reaction 
      method. HHV-6 was detected in 39% of the non-Hodgkin's lymphomas, in 52% of 
      Hodgkin's diseases, 64% of non-neoplastic lymph nodes, 23% of tumor metastases, 
      and 50% of salivary gland biopsies. When correlating the patients' ages with the 
      occurrence of HHV-6, we found a significantly higher percentage of positive 
      samples in patients younger than 60 years of age (54%) than in older patients 
      (35%). This age-related difference was found in all the lymphoproliferative 
      disorders studied as well as in salivary gland biopsies. Taking patient's ages 
      into account, we found no significant difference between the various groups of 
      disorders concerning the percentage of HHV-6-positive samples.
FAU - Hallas, C
AU  - Hallas C
AD  - Institute of Pathology, University of Wurzburg, Germany.
FAU - Neipel, F
AU  - Neipel F
FAU - Huettner, C
AU  - Huettner C
FAU - Schreiner, D
AU  - Schreiner D
FAU - Fleckenstein, B
AU  - Fleckenstein B
FAU - Muller-Hermelink, H K
AU  - Muller-Hermelink HK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diagn Mol Pathol
JT  - Diagnostic molecular pathology : the American journal of surgical pathology, part 
      B
JID - 9204924
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - DNA, Viral/analysis
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Infant
MH  - Lymphoproliferative Disorders/genetics/pathology/*virology
MH  - Middle Aged
MH  - Polymerase Chain Reaction
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1097/00019606-199609000-00004 [doi]
PST - ppublish
SO  - Diagn Mol Pathol. 1996 Sep;5(3):166-72. doi: 10.1097/00019606-199609000-00004.