PMID- 8866412
OWN - NLM
STAT- MEDLINE
DCOM- 19970328
LR  - 20210518
IS  - 1046-6673 (Print)
IS  - 1046-6673 (Linking)
VI  - 7
IP  - 8
DP  - 1996 Aug
TI  - Ovariectomy decreases plasma triglyceride levels and both prevents and alleviates 
      glomerular disease in uninephrectomized female analbuminemic rats.
PG  - 1189-97
AB  - Female Nagase analbuminemic rats (NAR) are profoundly hypertriglyceridemic and 
      develop proteinuria and glomerulosclerosis when aging and after uninephrectomy 
      (UNX). Ovariectomy (OVX) markedly decreases plasma triglyceride levels in this 
      species. This study evaluated whether decreasing triglyceride levels by OVX could 
      prevent renal disease or alleviate its progression in UNX female NAR. Female NAR 
      underwent OVX at 0, 12, 24, or 36 wk after UNX. In the absence of OVX, the 
      animals developed progressive proteinuria from 18 wk after UNX and showed 
      extensive glomerular sclerosis, lipid deposition, and hypertrophy at euthanasia 
      (49 wk after UNX). These changes were prevented by OVX carried out at 0 or 12 wk, 
      and attenuated by OVX at 24 wk after UNX. If performed at 36 wk after UNX, OVX 
      had no effect on glomerulosclerosis, although it reduced proteinuria. In 95% (20 
      of 21) of the rats with proteinuria over 10 mg/day, proteinuria decreased in the 
      first 6 wk after OVX. The percentage decrease in proteinuria correlated inversely 
      with the glomerulosclerosis score at euthanasia (r = -0.58, P < 0.01). OVX had no 
      effect on hyperfiltration and hyperperfusion in the UNX rats. OVX consistently 
      reduced plasma triglyceride levels in rats both with and without proteinuria, and 
      it also reduced plasma cholesterol, but only in conjunction with reduction in 
      proteinuria. It was concluded that OVX in UNX female NAR prevents 
      glomerulosclerosis if performed before proteinuria and attenuates further 
      development of established renal disease if performed in a timely manner. This 
      study's data suggest that in UNX female NAR, the lowering of plasma triglyceride 
      levels plays a central role in the renoprotective action of OVX.
FAU - Joles, J A
AU  - Joles JA
AD  - Department of Nephrology, Utrecht University, The Netherlands.
FAU - van Goor, H
AU  - van Goor H
FAU - van der Horst, M L
AU  - van der Horst ML
FAU - van Tol, A
AU  - van Tol A
FAU - Weening, J J
AU  - Weening JJ
FAU - Koomans, H A
AU  - Koomans HA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Soc Nephrol
JT  - Journal of the American Society of Nephrology : JASN
JID - 9013836
RN  - 0 (Serum Albumin)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Blood Viscosity
MH  - Body Weight
MH  - Disease Models, Animal
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Glomerulosclerosis, Focal Segmental/blood/complications/genetics/*prevention & 
      control/surgery
MH  - Hypertriglyceridemia/*blood/genetics/surgery
MH  - *Nephrectomy
MH  - *Ovariectomy
MH  - Proteinuria/etiology
MH  - Rats
MH  - Rats, Mutant Strains/*physiology
MH  - Renal Circulation
MH  - Serum Albumin/deficiency
MH  - Sex Characteristics
MH  - Triglycerides/*blood
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 10.1681/ASN.V781189 [doi]
PST - ppublish
SO  - J Am Soc Nephrol. 1996 Aug;7(8):1189-97. doi: 10.1681/ASN.V781189.