PMID- 8867597
OWN - NLM
STAT- MEDLINE
DCOM- 19970103
LR  - 20181130
IS  - 0196-3635 (Print)
IS  - 0196-3635 (Linking)
VI  - 16
IP  - 6
DP  - 1995 Nov-Dec
TI  - Impaired secretory function of the prostate in men with oligo-asthenozoospermia.
PG  - 491-8
AB  - The secretory function of the human prostate and the seminal vesicles is a 
      prerequisite for gel formation and liquefaction of semen, but the relation to 
      poor sperm motility and low sperm count in infertile men remains to be clarifyed. 
      Our aim was to evaluate the secretory function of the prostate and the seminal 
      vesicles in normozoospermic men (n = 35) and in asthenozoospermic men, who were 
      all also oligozoospermic (n = 27). All 62 subjects belonged to couples undergoing 
      routine infertility evaluation. In liquefied seminal fluid we measured the 
      concentrations of fructose and protein C inhibitor (PCI) contributed by the 
      seminal vesicles, PCI complexed to prostate-specific antigen (PSA), and the 
      prostatic contribution of zinc, PSA, acid phosphatase (PAP), 
      beta-microseminoprotein (beta-MSP), and Zn alpha 2-glycoprotein (Zn alpha 2-GP). 
      The concentration of each prostatic secretory protein correlated significantly 
      with that of zinc (P < 0.01) in both the normozoospermic (NZS) and 
      oligo-asthenozoospermic (OAZS) subgroups, but the PCI concentration did not 
      correlate significantly with that of fructose. There was no significant 
      difference between the NZS and OAZS subgroups in ejaculate volume or secretory 
      contribution from the seminal vesicles, whereas the OAZS subgroup was 
      characterized by significantly lower secretory contributions of Zn alpha 2-GP (P 
      = 0.001), Zn, PSA, PAP (P < 0.01), and beta-MSP (P < 0.05). The two subgroups did 
      not differ significantly in the serum concentration of luteinizing hormone (LH), 
      testosterone, or sex hormone-binding globulin (SHBG). The results thus suggest 
      the secretory contribution of major prostatic proteins and zinc per ejaculate to 
      be significantly decreased in oligo-asthenozoospermic men. The importance of this 
      finding in relation to poor sperm count and motility as indicators of impaired 
      gonadal function requires further investigation.
FAU - Ahlgren, G
AU  - Ahlgren G
AD  - Department of Urology, Malmo University Hospital, Sweden.
FAU - Rannevik, G
AU  - Rannevik G
FAU - Lilja, H
AU  - Lilja H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Androl
JT  - Journal of andrology
JID - 8106453
RN  - 0 (Biomarkers)
RN  - 0 (Hormones)
RN  - 0 (Proteins)
SB  - IM
MH  - Adult
MH  - Biomarkers
MH  - Cell Survival
MH  - Hormones/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oligospermia/*metabolism
MH  - Prostate/*metabolism
MH  - Proteins/metabolism
MH  - Reference Values
MH  - Seminal Vesicles/metabolism
MH  - Spermatozoa/*physiology
EDAT- 1995/11/01 00:00
MHDA- 1995/11/01 00:01
CRDT- 1995/11/01 00:00
PHST- 1995/11/01 00:00 [pubmed]
PHST- 1995/11/01 00:01 [medline]
PHST- 1995/11/01 00:00 [entrez]
PST - ppublish
SO  - J Androl. 1995 Nov-Dec;16(6):491-8.