PMID- 8867725
OWN - NLM
STAT- MEDLINE
DCOM- 19961121
LR  - 20191024
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 63
IP  - 2
DP  - 1996 Feb
TI  - Autoimmune hemolytic anemia in allergic granulomatous angitis (Churg-Strauss 
      syndrome).
PG  - 149-54
AB  - We describe a patient with allergic granulomatous angitis who developed 
      autoimmune hemolytic anemia (AIHA). A 44-year-old male had been suffering from 
      bronchial asthma. On admission, laboratory tests revealed the presence of severe 
      eosinophilia (21,500/microliters), elevation of total immunoglobulin E (IgE), 
      high lactic dehydrogenase (LDH) and low haptoglobin levels, in addition to 
      moderate reticulocytosis. During admission, the patient showed almost 
      simultaneous occurrence of vasculitis in the extremities, severe hemolysis and 
      exacerbation of asthma in relation to the progression of eosinophilia. Both IgM 
      and IgG autoantibodies were considered to be responsible for hemolysis. 
      Interestingly, serum levels of interleukin-4 (IL-4) and IL-5 were increased in 
      association with eosinophilia and increased IgE production. These findings 
      suggest that the AIHA in this patient is mediated or enhanced at least partly by 
      high IL-4 and IL-5 production. Although AIHA in this syndrome is very rare, it 
      should be considered as a clinical manifestation.
FAU - Kojima, K
AU  - Kojima K
AD  - Second Department of Internal Medicine, Okayama University Medical School, Japan.
FAU - Omoto, E
AU  - Omoto E
FAU - Katayama, Y
AU  - Katayama Y
FAU - Uno, M
AU  - Uno M
FAU - Takada, I
AU  - Takada I
FAU - Kimura, G
AU  - Kimura G
FAU - Kanehiro, A
AU  - Kanehiro A
FAU - Tada, S
AU  - Tada S
FAU - Hayashi, K
AU  - Hayashi K
FAU - Kimura, I
AU  - Kimura I
FAU - Sanada, H
AU  - Sanada H
FAU - Harada, M
AU  - Harada M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Blood Proteins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 0 (Interleukin-5)
RN  - 207137-56-2 (Interleukin-4)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Adult
MH  - Anemia, Hemolytic, Autoimmune/blood/*etiology
MH  - Blood Proteins/metabolism
MH  - Churg-Strauss Syndrome/*complications
MH  - Eosinophil Granule Proteins
MH  - Humans
MH  - Interleukin-4/blood
MH  - Interleukin-5/blood
MH  - Male
MH  - *Ribonucleases
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 0925571095004270 [pii]
AID - 10.1016/0925-5710(95)00427-0 [doi]
PST - ppublish
SO  - Int J Hematol. 1996 Feb;63(2):149-54. doi: 10.1016/0925-5710(95)00427-0.