PMID- 8867727
OWN - NLM
STAT- MEDLINE
DCOM- 19961121
LR  - 20191024
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 63
IP  - 2
DP  - 1996 Feb
TI  - Cyclosporine-related encephalopathy following allogeneic bone marrow 
      transplantation.
PG  - 161-4
AB  - A 46-year-old man with chronic myelogenous leukemia received allogeneic bone 
      marrow transplantation (BMT) from a partially human leukocyte antigen 
      (HLA)-mismatched sibling. Cyclosporine (CYA)-related encephalopathy developed on 
      days 10 and 21 following BMT, and CYA-related thrombotic thrombocytopenic purpura 
      (TTP) developed on day 45 following BMT. We measured serum concentrations of 
      thrombomodulin (TM) as a marker of endothelial injury. The concentrations of TM 
      were increased during the encephalopathy or TTP and decreased following recovery. 
      Since CYA can cause endothelial injury, we suggest that CYA-induced endothelial 
      injury is common to the pathogenesis of both the encephalopathy and the TTP. CYA 
      therapy should be reinstituted with extreme caution in patients with a past 
      history of CYA-related encephalopathy, since readministration of a low-dose CYA 
      can evoke the immediate return of the encephalopathy.
FAU - Teshima, T
AU  - Teshima T
AD  - Department of Internal Medicine, Kitakyushu Municipal Medical Center, Fukuoka, 
      Japan.
FAU - Miyoshi, T
AU  - Miyoshi T
FAU - Ono, M
AU  - Ono M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Brain Diseases/*chemically induced
MH  - Cyclosporine/*adverse effects
MH  - Humans
MH  - Immunosuppressive Agents/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Purpura, Thrombotic Thrombocytopenic/chemically induced
MH  - Transplantation, Homologous
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - 0925571095004319 [pii]
AID - 10.1016/0925-5710(95)00431-9 [doi]
PST - ppublish
SO  - Int J Hematol. 1996 Feb;63(2):161-4. doi: 10.1016/0925-5710(95)00431-9.