PMID- 8869264
OWN - NLM
STAT- MEDLINE
DCOM- 19970103
LR  - 20161020
IS  - 0862-8408 (Print)
IS  - 0862-8408 (Linking)
VI  - 44
IP  - 5
DP  - 1995
TI  - The influence of ascorbic acid on the hepatic cytochrome P-450, and glutathione 
      in guinea-pigs exposed to 2,4-dichlorophenol.
PG  - 301-5
AB  - Chlorophenols, mainly used as biocides, are compounds with a wide spectrum of 
      toxic effects including teratogenic and carcinogenic actions. In this study, the 
      effects of 2,4-dichlorophenol (2,4-DCP) on hepatic microsomal cytochrome P-450, 
      NADPH-cytochrome c reductase activity, liver ascorbic acid (AA) and glutathione 
      (GSH) content were studied in guinea-pigs with a low (2 mg/day/animal) or a high 
      (50 mg/day/animal) ascorbic acid intake. The high AA intake significantly 
      increased liver AA and GSH levels. There was a clear-cut correlation between 
      liver AA and GSH levels. Administration of 2,4-DCP significantly decreased 
      cytochrome P-450 and NADPH-cytochrome c reductase activity in hepatic microsomes 
      isolated from guinea-pigs with the low AA intake. Such a reduction was not 
      observed in intoxicated guinea-pigs with the high AA intake. The results suggest 
      that AA can play a protective role in 2,4-DCP toxicity.
FAU - Nagyova, A
AU  - Nagyova A
AD  - Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
FAU - Ginter, E
AU  - Ginter E
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Chlorophenols)
RN  - 0 (Cytochrome P-450 Enzyme Inhibitors)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - GAN16C9B8O (Glutathione)
RN  - PQ6CK8PD0R (Ascorbic Acid)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Animals
MH  - Ascorbic Acid/*pharmacology
MH  - Chlorophenols/*pharmacology
MH  - Cytochrome P-450 Enzyme Inhibitors
MH  - Cytochrome P-450 Enzyme System/*metabolism
MH  - Glutathione/*metabolism
MH  - Guinea Pigs
MH  - Liver/drug effects/*metabolism
MH  - Male
MH  - Microsomes, Liver/drug effects/metabolism
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
PST - ppublish
SO  - Physiol Res. 1995;44(5):301-5.