PMID- 8870121
OWN - NLM
STAT- MEDLINE
DCOM- 19970403
LR  - 20191101
IS  - 0146-0005 (Print)
IS  - 0146-0005 (Linking)
VI  - 20
IP  - 3
DP  - 1996 Jun
TI  - Effect of modulators of hypoxic pulmonary vasoconstriction on the response to 
      inhaled nitric oxide in a neonatal model of severe pulmonary atelectasis.
PG  - 186-93
AB  - Hypoxic pulmonary vasoconstriction (HPV) is an intrinsic mechanism that 
      facilitates ventilation to perfusion matching and preservation of oxygenation. We 
      investigated the neonatal HPV response from extensive atelectasis and tested the 
      hypothesis that (I) the resulting hypoxemia is corrected by inhaled nitric oxide 
      (NO); (2) the "pulmonary steal" of blood away from hypoxic area is further 
      improved by modulators of the HPV. Intratracheal injection of steel beads in 32 
      piglets (7 to 20 days) resulted in atelectasis of 50% to 75% of the lungs. The 
      piglets were then randomized to receive saline (control), indomethacin (IND) 2 
      mg/kg, doxapram (DOX) 0.5 mg/kg/h or almitrine (ALM) 4 micrograms/kg/min. After 
      30 minutes, all animals were subjected to NO at 40 ppm. Atelectasis resulted in 
      severe impairment in oxygenation (PaO2 - 105 +/- 6 mm Hg, AaDO2 = 536 +/- 9 mm 
      Hg; shunt fraction = 31% +/- 2%) and moderate pulmonary hypertension. Mean 
      pulmonary artery pressure (PAP) increased to 35 +/- 0.8 mm Hg. NO reduced 
      pulmonary vascular resistance (PVR) from 128 +/- 14 mm Hg/kg/mL/min to 74 +/- 9 
      mm Hg/kg/mL/min and improved gas exchange (PaO2 = 180 +/- 50 and AaDO2 = 438 +/- 
      50 mm Hg). Following the development of atelectasis, the peripheral chemoreceptor 
      agonists (ALM and DOX) did not modify gas exchange and had no significant 
      cardiovascular effect. ALM and DOX failed to enhance the response to NO. IND did 
      not alter HPV, but prevented the improvement in gas exchange associated with 
      NO-induced pulmonary vasodilation.
FAU - Eyal, F G
AU  - Eyal FG
AD  - Division of Neonatology, University of South Alabama, Mobile, USA.
FAU - Hachey, W E
AU  - Hachey WE
FAU - Curtet-Eyal, N L
AU  - Curtet-Eyal NL
FAU - Kellum, F E
AU  - Kellum FE
FAU - Alpan, G
AU  - Alpan G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Semin Perinatol
JT  - Seminars in perinatology
JID - 7801132
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Administration, Inhalation
MH  - Airway Obstruction/complications/*physiopathology
MH  - Animals
MH  - Animals, Newborn
MH  - Disease Models, Animal
MH  - Hemodynamics/drug effects
MH  - Hypoxia/*physiopathology
MH  - Lung/blood supply/*drug effects
MH  - Nitric Oxide/*therapeutic use
MH  - Pulmonary Atelectasis/*drug therapy/etiology/physiopathology
MH  - Swine
MH  - Vasoconstriction/*physiology
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - S0146-0005(96)80047-4 [pii]
AID - 10.1016/s0146-0005(96)80047-4 [doi]
PST - ppublish
SO  - Semin Perinatol. 1996 Jun;20(3):186-93. doi: 10.1016/s0146-0005(96)80047-4.