PMID- 8870796
OWN - NLM
STAT- MEDLINE
DCOM- 19970110
LR  - 20190914
IS  - 0065-1419 (Print)
IS  - 0065-1419 (Linking)
VI  - 67
DP  - 1996
TI  - Delayed neuronal damage following focal ischemic injury in stroke-prone 
      spontaneously hypertensive rats.
PG  - 24-7
AB  - We detected the delayed accumulation of 45Ca in the lateral part of the striatum 
      3 days after distal middle cerebral artery (MCA) occlusion in stroke-prone 
      spontaneously hypertensive rats (SHRSP). However, the mechanism of delayed 
      neuronal damage in the striatum, which is not supplied by the occluded MCA, 
      remains unknown. The aim of this study was to evaluate whether the delayed damage 
      involves alterations in the extracellular release of neurotransmitter monoamines 
      and amino acids. Chronological changes in the distribution of neuronal damage 
      were determined by 45Ca autoradiography. The microdialysis probes were inserted 
      into either the medial or lateral part of the striatum. The dialysate content of 
      monoamines, their metabolites and amino acids was determined by analytical 
      techniques. 45Ca accumulation was detected only in the cortex and corpus callosum 
      by 24 hours postischemia and extended to the pyramidal tract, thalamus and 
      lateral portion of the striatum by 3 days. A 3-fold increase in glutamate 
      content, and a 2-fold increase in dopamine content were observed only in the 
      lateral part of the striatum following ischemia. The results suggest that 
      excessive release of glutamate and dopamine is related to delayed neuronal damage 
      that occurs in the lateral part of the striatum in this ischemic model.
FAU - Shima, K
AU  - Shima K
AD  - Department of Neurosurgery, National Defense Medical College, Japan.
FAU - Shirotani, T
AU  - Shirotani T
FAU - Chigasaki, H
AU  - Chigasaki H
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - Acta Neurochir Suppl
JT  - Acta neurochirurgica. Supplement
JID - 100962752
RN  - 0 (Amino Acids)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Neurotransmitter Agents)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Amino Acids/metabolism
MH  - Animals
MH  - Autoradiography
MH  - Biogenic Monoamines/metabolism
MH  - Brain/metabolism/*pathology
MH  - Brain Ischemia/metabolism/*pathology
MH  - Calcium/metabolism
MH  - Cerebrovascular Disorders/genetics
MH  - Extracellular Space/metabolism
MH  - Genetic Predisposition to Disease
MH  - Male
MH  - Microdialysis
MH  - Neurons/*pathology
MH  - Neurotransmitter Agents/metabolism
MH  - Rats
MH  - Rats, Inbred SHR/genetics
MH  - Time Factors
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1007/978-3-7091-6894-3_5 [doi]
PST - ppublish
SO  - Acta Neurochir Suppl. 1996;67:24-7. doi: 10.1007/978-3-7091-6894-3_5.