PMID- 8871046
OWN - NLM
STAT- MEDLINE
DCOM- 19970122
LR  - 20171116
IS  - 0904-1850 (Print)
IS  - 0904-1850 (Linking)
VI  - 22
DP  - 1996 Aug
TI  - Pairs of surface molecules involved in human IgE regulation: CD23-CD21 and 
      CD40-CD40L.
PG  - 63s-66s
AB  - At least two cell-derived signals have been shown to be necessary for the 
      induction of immunoglobulin isotype switching in B-cells. The first signal is 
      given by either of the soluble lymphokines, interleukin (IL)-4 or IL-13, which 
      induce germline epsilon transcript expression, but this alone is insufficient to 
      trigger secretion of immunoglobulin E (IgE). The second signal is provided by a 
      physical interaction between B-cells and activated T-cells, basophils and mast 
      cells, and it has been shown that the CD40/CD40 ligand (CD40L) pairing is crucial 
      for mediating IgE synthesis. In hyper-immunoglobulin M1 (HIGM1) syndrome, which 
      is characterized by greatly decreased levels of immunoglobulin G, A and E (IgG, 
      IgA and IgE), there are mutations in the CD40L resulting in a completely 
      non-functional extracellular domain. The CD40L is, therefore, playing a central 
      role in immunoglobulin isotype switching. Amongst the numerous pairs of surface 
      adhesion molecules, the CD23-CD21 pair seems to play a key role in the generation 
      of IgE. The CD23 molecule is positively and negatively regulated by factors which 
      increase or decrease IgE production, respectively. Antibodies to CD23 have been 
      shown to inhibit IL-4-induced human IgE production in vitro and to inhibit 
      antigen-specific IgE responses in a rat model, in an isotype selective manner. 
      CD23 interacts with CD21 on B-cells, preferentially driving IgE production. CD23 
      recognizes two main epitopes on the CD21 molecule. One region consists of short 
      consensus repeat (SCR) sequences 1-2 and the other of SCR 5-8. In the latter 
      region, Asn 370 and 295 are critical in the interaction with the lectin CD23. 
      Therefore, a restricted number of cytokines and surface molecules seems to 
      selectively regulate human immunoglobulin E synthesis.
FAU - Bonnefoy, J Y
AU  - Bonnefoy JY
AD  - Glaxo Institute for Molecular Biology, Planles-Ouates,Geneva, Switzerland.
FAU - Gauchat, J F
AU  - Gauchat JF
FAU - Life, P
AU  - Life P
FAU - Graber, P
AU  - Graber P
FAU - Mazzei, G
AU  - Mazzei G
FAU - Aubry, J P
AU  - Aubry JP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur Respir J Suppl
JT  - The European respiratory journal. Supplement
JID - 8910681
RN  - 0 (Antigens, Surface)
RN  - 0 (CD40 Antigens)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Interleukin-13)
RN  - 0 (Receptors, Complement 3d)
RN  - 0 (Receptors, IgE)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antigens, Surface/*immunology/physiology
MH  - B-Lymphocytes/immunology
MH  - CD40 Antigens/genetics/*immunology/physiology
MH  - Eosinophils/immunology
MH  - Humans
MH  - Hypergammaglobulinemia/*immunology
MH  - Immunoglobulin A/biosynthesis
MH  - Immunoglobulin Class Switching/*immunology
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Immunoglobulin M/*biosynthesis
MH  - Interleukin-13/immunology
MH  - Interleukin-4/immunology
MH  - Mast Cells/immunology
MH  - Rats
MH  - Receptors, Complement 3d/*immunology/physiology
MH  - Receptors, IgE/genetics/*immunology/physiology
MH  - Signal Transduction
MH  - Syndrome
RF  - 48
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J Suppl. 1996 Aug;22:63s-66s.