PMID- 8872846
OWN - NLM
STAT- MEDLINE
DCOM- 19970110
LR  - 20131121
IS  - 0950-9240 (Print)
IS  - 0950-9240 (Linking)
VI  - 10 Suppl 3
DP  - 1996 Sep
TI  - High-altitude pulmonary hypertension: effects of captopril on pulmonary and 
      systemic arterial pressures.
PG  - S141-2
AB  - The purpose of investigation was the assessment of the effect of captopril on 
      both systemic (Pa) and pulmonary arterial pressures (PPA) in patients with 
      high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44 +/- 
      6.8 years) with HAPH and mild-to-moderate systemic arterial hypertension were 
      included in the study. All the patients underwent right heart catheterization 
      with measurements of systolic PPA (PPA,syst), mean PPA (PPA) and diastolic PPA 
      (PPA,diast). After a 4 week placebo phase, patients with PPA,syst > 25 mm Hg, PPA 
      > 15 mm Hg and systemic diastolic blood pressure (Pa,diast) > 100 mm Hg received 
      captopril (50-75 mg at 08.00) for a period of 12 weeks. The statistical 
      evaluation of the results were made using the Student's t-test. It was found that 
      captopril significantly decreases PPA and Pa.
FAU - Niazova, Z A
AU  - Niazova ZA
AD  - Cukurova University, Balcali Hospital, Department of Cardiology, Adana, Turkey.
FAU - Batyraliev, T A
AU  - Batyraliev TA
FAU - Aikimbaev, K S
AU  - Aikimbaev KS
FAU - Kudaiberdieva, G Z
AU  - Kudaiberdieva GZ
FAU - Akgul, F
AU  - Akgul F
FAU - Soodanbekova, Y K
AU  - Soodanbekova YK
FAU - Birand, A
AU  - Birand A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Antihypertensive Agents)
RN  - 9G64RSX1XD (Captopril)
SB  - IM
MH  - Adult
MH  - *Altitude
MH  - Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
MH  - Antihypertensive Agents/*therapeutic use
MH  - Blood Pressure/*drug effects
MH  - Captopril/*therapeutic use
MH  - Humans
MH  - Hypertension, Pulmonary/*drug therapy/*etiology/physiopathology
MH  - Middle Aged
MH  - Pulmonary Circulation/*drug effects
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
PST - ppublish
SO  - J Hum Hypertens. 1996 Sep;10 Suppl 3:S141-2.