PMID- 8875198
OWN - NLM
STAT- MEDLINE
DCOM- 19970116
LR  - 20190826
IS  - 0302-2838 (Print)
IS  - 0302-2838 (Linking)
VI  - 30
IP  - 2
DP  - 1996
TI  - Potential markers of aggressiveness in prostatic intraepithelial neoplasia 
      detected by fluorescence in situ hybridization.
PG  - 177-84
AB  - OBJECTIVE: High-grade prostatic intraepithelial neoplasia (PIN) represents the 
      most likely precursor of prostatic adenocarcinoma. In this review, we discuss the 
      utility of different techniques of interphase fluorescence in situ hybridization 
      (FISH) in evaluating the genetic association between PIN and adenocarcinoma. 
      METHODS AND RESULTS: Although the proportion of PIN and prostatic carcinoma foci 
      that have chromosomal anomalies is similar, foci of carcinoma often have more 
      alterations. This supports the hypothesis that PIN is a precursor of carcinoma. 
      In some prostates, however, PIN foci have more alterations than matched carcinoma 
      foci, suggesting that PIN foci can sometimes undergo more extensive chromosome 
      evolution than carcinoma foci. Gain of chromosome 8 is the most common numerical 
      alteration in prostatic carcinoma and PIN foci, and is associated with increasing 
      cancer stage and grade. Thus, genes on chromosome 8 may play a role in the 
      initiation and progression of prostatic carcinoma. One primary tumor focus 
      usually shares chromosomal anomalies with associated lymph node metastases, 
      implying that only one primary lesion acquires genetic alterations that allow it 
      to escape the prostate. CONCLUSIONS: PIN and prostatic carcinoma have similar 
      genetic changes. This supports the hypothesis that PIN is often a precursor of 
      carcinoma. Genes on chromosome 8 may play a role in both initiation and 
      progression of prostatic carcinoma.
FAU - Qian, J
AU  - Qian J
AD  - Department of Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Jenkins, R B
AU  - Jenkins RB
FAU - Bostwick, D G
AU  - Bostwick DG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Eur Urol
JT  - European urology
JID - 7512719
SB  - IM
MH  - Adenocarcinoma/*genetics/secondary
MH  - Chromosome Aberrations/genetics
MH  - Chromosome Disorders
MH  - Chromosomes, Human, Pair 7/metabolism
MH  - Chromosomes, Human, Pair 8/metabolism
MH  - Flow Cytometry
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Ploidies
MH  - Prostatic Intraepithelial Neoplasia/*genetics/metabolism
MH  - Prostatic Neoplasms/*genetics
RF  - 49
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1159/000474167 [doi]
PST - ppublish
SO  - Eur Urol. 1996;30(2):177-84. doi: 10.1159/000474167.