PMID- 8876746
OWN - NLM
STAT- MEDLINE
DCOM- 19970123
LR  - 20061115
IS  - 0001-6772 (Print)
IS  - 0001-6772 (Linking)
VI  - 158
IP  - 1
DP  - 1996 Sep
TI  - High afterload during 10 min of regional ischaemia affects diastolic creep but 
      not systolic function in reperfused (stunned) myocardium.
PG  - 39-44
AB  - The effect of afterload during regional ischaemia on myocardial stunning was 
      studied in 15 pentobarbital anaesthetized cats. 10 min occlusion of the left 
      anterior descending artery (LAD) was followed by 60 min of reperfusion. Afterload 
      was decreased by intravenous infusion of nitroglycerine 3-8 micrograms kg-1 min-1 
      in group I (n = 8); left ventricular peak systolic pressure (LVSP) 84 +/- 4 mmHg 
      (mean +/- SEM) during coronary artery occlusion. In group II (n = 7) LVSP was 
      increased to 188 +/- 10 mmHg by inflating an intraaortic balloon during coronary 
      artery occlusion. Regional function in the LAD perfused region was evaluated by 
      cross-oriented sonomicrometry. Myocardial tissue blood flow was evaluated by 
      radio-labelled microspheres. Afterload alterations did not affect regional 
      systolic shortening (10.8 +/- 2.0% vs. 11.0 +/- 1.5% in group I and II, 
      respectively, after 60 min of reperfusion). However, increased end-diastolic 
      dimensions (diastolic creep) in both the circumferential and longitudinal 
      segments were markedly more pronounced in the high afterload group (group II). 
      Also important, the markedly increased myocardial tissue blood flow during 
      reperfusion in group II as compared with group I (2.30 +/- 0.18 vs. 1.34 +/- 0.08 
      mL min-1 g-1 and 2.58 +/- 0.23 vs. 1.49 +/- 0.07 mL min-1 g-1 in subepicardial 
      and subendocardial layers in the LAD perfused region) suggests that increased 
      diastolic creep increased metabolic demands. This study indicates that passive 
      stretching of the ischaemic area during coronary artery occlusion is an important 
      mechanism behind diastolic creep.
FAU - Rynning, S E
AU  - Rynning SE
AD  - Surgical Research Laboratory, Haukeland University Hospital, Bergen, Norway.
FAU - Brunvand, H
AU  - Brunvand H
FAU - Birkeland, S
AU  - Birkeland S
FAU - Hexeberg, E
AU  - Hexeberg E
FAU - Grong, K
AU  - Grong K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Physiol Scand
JT  - Acta physiologica Scandinavica
JID - 0370362
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/physiology
MH  - Cardiac Output/physiology
MH  - Cats
MH  - Coronary Circulation/physiology
MH  - Diastole/*physiology
MH  - Male
MH  - Microspheres
MH  - Myocardial Ischemia/*physiopathology
MH  - Myocardial Reperfusion Injury/*physiopathology
MH  - Systole/*physiology
MH  - Vasodilation/physiology
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1046/j.1365-201X.1996.520295000.x [doi]
PST - ppublish
SO  - Acta Physiol Scand. 1996 Sep;158(1):39-44. doi: 
      10.1046/j.1365-201X.1996.520295000.x.