PMID- 8878463
OWN - NLM
STAT- MEDLINE
DCOM- 19961202
LR  - 20190512
IS  - 0910-5050 (Print)
IS  - 1876-4673 (Electronic)
IS  - 0910-5050 (Linking)
VI  - 87
IP  - 9
DP  - 1996 Sep
TI  - Genetic screening in hereditary multiple endocrine neoplasia type 1: absence of a 
      founder effect among Japanese families.
PG  - 985-94
AB  - Ten Japanese families with hereditary multiple endocrine neoplasia type 1 (MEN1) 
      were examined. Five DNA polymorphic markers on the long arm of chromosome 11 were 
      analyzed for genetic screening of MEN1 in members of affected families, and 
      disease carriers were identified before clinical manifestations. Unlike MEN1 
      families in Newfoundland or in Tasmania, no consistent haplotypes were segregated 
      with the disease in the Japanese families when defined by 5 nearby markers. The 
      identification of asymptomatic disease carriers is of substantial clinical 
      importance for early management, genetic counseling and to avoid unnecessary 
      screening for non-disease carriers. However, genetic screening of family members 
      by polymorphic markers could be useful only to each family, and no generally 
      applicable markers were found for Japanese subjects with MEN1.
FAU - Sakurai, A
AU  - Sakurai A
AD  - Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School 
      of Medicine, Matsumoto.
FAU - Katai, M
AU  - Katai M
FAU - Itakura, Y
AU  - Itakura Y
FAU - Nakajima, K
AU  - Nakajima K
FAU - Baba, K
AU  - Baba K
FAU - Hashizume, K
AU  - Hashizume K
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (DNA, Satellite)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Child
MH  - DNA, Satellite/genetics
MH  - Female
MH  - *Founder Effect
MH  - Genetic Carrier Screening
MH  - *Genetic Testing
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/blood/*genetics
MH  - Pedigree
MH  - Polymorphism, Genetic
PMC - PMC5921204
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
PMCR- 1996/09/01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
PHST- 1996/09/01 00:00 [pmc-release]
AID - 0910505096859072 [pii]
AID - CAE985 [pii]
AID - 10.1111/j.1349-7006.1996.tb02130.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 1996 Sep;87(9):985-94. doi: 10.1111/j.1349-7006.1996.tb02130.x.