PMID- 8879099
OWN - NLM
STAT- MEDLINE
DCOM- 19970204
LR  - 20190728
IS  - 0264-410X (Print)
IS  - 0264-410X (Linking)
VI  - 14
IP  - 11
DP  - 1996 Aug
TI  - Hepatitis A vaccine responses in HIV-positive persons with haemophilia.
PG  - 1039-41
AB  - The safety and immunogenicity of subcutaneously (s.c.) administered hepatitis A 
      (HA) vaccine was evaluated in HIV positive and negative patients with haemophilia 
      and healthy male controls. The vaccine was well tolerated. Seroconversion 
      occurred among all controls after one dose of vaccine but was delayed among 
      patients, particularly if HIV-positive-4 of 17 (24%) failed to respond to three 
      doses of vaccine. Following the third dose of vaccine, geometric mean titres were 
      significantly higher among controls (1354) than among HIV infected patients (204) 
      (P < 0.05). Non-responders failed to develop an immune response following 
      boosting with high titre vaccine. Patients with haemophilia may be vaccinated 
      against HA s.c. but consideration should be given to ensuring that HIV-positive 
      individuals with haemophilia and other immunosuppressed individuals should have 
      their immune responses checked since additional booster doses or passive 
      prophylaxis may be necessary in such individuals.
FAU - Tilzey, A J
AU  - Tilzey AJ
AD  - Guy's and St Thomas' Hospital Trust, St Thomas' Hospital, London, UK.
FAU - Palmer, S J
AU  - Palmer SJ
FAU - Harrington, C
AU  - Harrington C
FAU - O'Doherty, M J
AU  - O'Doherty MJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Hepatitis A Antibodies)
RN  - 0 (Hepatitis A Vaccines)
RN  - 0 (Hepatitis Antibodies)
RN  - 0 (Vaccines, Inactivated)
RN  - 0 (Viral Hepatitis Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - HIV Infections/*immunology
MH  - Hemophilia A/*immunology
MH  - Hepatitis A Antibodies
MH  - Hepatitis A Vaccines
MH  - Hepatitis Antibodies/*biosynthesis
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Male
MH  - Middle Aged
MH  - Vaccines, Inactivated/immunology
MH  - Viral Hepatitis Vaccines/administration & dosage/adverse effects/*immunology
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 0264410X96000564 [pii]
AID - 10.1016/0264-410x(96)00056-4 [doi]
PST - ppublish
SO  - Vaccine. 1996 Aug;14(11):1039-41. doi: 10.1016/0264-410x(96)00056-4.