PMID- 8879201
OWN - NLM
STAT- MEDLINE
DCOM- 19961213
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 184
IP  - 4
DP  - 1996 Oct 1
TI  - Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 
      2 immune responses.
PG  - 1295-304
AB  - A number of investigations have established the critical role of interleukin 4 
      (IL-4) in mediating the development of T helper (Th)2 effector cells in vitro and 
      in vivo. Despite intensive study, the origin of the IL-4 required for Th2 priming 
      and differentiation remains unclear. Natural killer (NK)1.1+ alpha/beta T cell 
      receptor+ T(NT) cells, a unique lineage of cells capable of producing large 
      amounts of IL-4 after activation in vivo, are important candidates for directing 
      Th2 priming. These cells are selected by the nonpolymorphic major 
      histocompatibility complex (MHC) class I molecule, CD1, and are deficient in beta 
      2-microglobulin (beta 2m)-null mice. We used beta 2m-deficient mice on both 
      BALB/c and C57BL/6 backgrounds to examine their capacity to mount Th2 immune 
      responses after challenge with a number of well-characterized antigens 
      administered by a variety of routes. As assessed by immunization with protein 
      antigen, infection with Leishmania major, embolization with eggs of Schistosoma 
      mansoni, intestinal infection with Nippostrongylus brasiliensis, or induction of 
      airway hyperreactivity to aerosolized antigen, beta 2m-deficient mice developed 
      functional type 2 immune responses that were not substantially different than 
      those in wild-type mice. Production of IL-4 and the generation of immunoglobulin 
      E (IgE) and eosinophil responses were preserved as assessed by a variety of 
      assays. Collectively, these results present a comprehensive analysis of type 2 
      immune responses in beta 2m-deficient mice, and indicate that beta 2m-dependent 
      NT cells are not required for Th2 development in vivo.
FAU - Brown, D R
AU  - Brown DR
AD  - Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 
      Illinois 60637, USA.
FAU - Fowell, D J
AU  - Fowell DJ
FAU - Corry, D B
AU  - Corry DB
FAU - Wynn, T A
AU  - Wynn TA
FAU - Moskowitz, N H
AU  - Moskowitz NH
FAU - Cheever, A W
AU  - Cheever AW
FAU - Locksley, R M
AU  - Locksley RM
FAU - Reiner, S L
AU  - Reiner SL
LA  - eng
GR  - AI-01309/AI/NIAID NIH HHS/United States
GR  - AI-07090/AI/NIAID NIH HHS/United States
GR  - AI-26918/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antigens)
RN  - 0 (Antigens, Ly)
RN  - 0 (Antigens, Surface)
RN  - 0 (Klrb1c protein, mouse)
RN  - 0 (Lectins, C-Type)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily B)
RN  - 0 (Proteins)
RN  - 0 (beta 2-Microglobulin)
RN  - 9013-72-3 (Hemocyanins)
RN  - FV4Y0JO2CX (keyhole-limpet hemocyanin)
SB  - IM
MH  - Animals
MH  - *Antigens
MH  - Antigens, Ly
MH  - Antigens, Surface
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Granuloma/immunology
MH  - Hemocyanins/immunology
MH  - Immunity
MH  - Killer Cells, Natural/*immunology
MH  - Lectins, C-Type
MH  - Leishmaniasis, Cutaneous/immunology
MH  - Lung Diseases, Parasitic/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mucous Membrane/immunology
MH  - NK Cell Lectin-Like Receptor Subfamily B
MH  - *Proteins
MH  - Schistosomiasis mansoni/immunology
MH  - Strongylida Infections/immunology
MH  - T-Lymphocyte Subsets/*immunology
MH  - Th2 Cells/*immunology
MH  - beta 2-Microglobulin/*deficiency
PMC - PMC2192844
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
PMCR- 1997/04/01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
PHST- 1997/04/01 00:00 [pmc-release]
AID - 97033504 [pii]
AID - 10.1084/jem.184.4.1295 [doi]
PST - ppublish
SO  - J Exp Med. 1996 Oct 1;184(4):1295-304. doi: 10.1084/jem.184.4.1295.