PMID- 8880106
OWN - NLM
STAT- MEDLINE
DCOM- 19970130
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 9
IP  - 9
DP  - 1996 Sep
TI  - Total serum IgE is associated with asthma independently of specific IgE levels. 
      The Spanish Group of the European Study of Asthma.
PG  - 1880-4
AB  - In this study we aimed to assess whether the association between asthma (defined 
      by symptoms and bronchial responsiveness) and total immunoglobulin E (IgE) levels 
      was independent of specific IgE levels to common aeroallergens. A general 
      population-based sample, supplemented with symptomatic individuals, comprising 
      1,916 young adults, aged 20-44 years, from five areas of Spain, performed a 
      face-to-face respiratory questionnaire, and spirometry, and had total and 
      specific serum IgE levels to mites, pets and moulds recorded. In 1,626 of the 
      subjects, a dose-response methacholine challenge test was completed. Subjects 
      reporting current attacks of asthma showed an association with total IgE (odds 
      ratio (OR) for IgE > 100 kU.L-1 = 4.73, 95% confidence intervals (95% CI) = 
      2.01-11.12, adjusted for specific IgE, sex, age, smoking, forced expiratory 
      volume in one second (FEV1), and area), which did not vary by bronchial 
      responsiveness. The association between total IgE and asthma also occurred among 
      those with negative specific IgE antibodies (OR 18.0; 95% CI 13.9-120). 
      Individuals with current wheezing and bronchial responsiveness without attacks of 
      asthma also showed an adjusted association with total IgE (OR 4.96; 95% CI 
      2.32-10.6), which remained for persons without specific IgE (OR 5.86; 95% CI 
      2.18-1.7). These findings reinforce previous evidence that asthma is associated 
      with increased levels of total IgE, even in subjects negative for specific IgE to 
      common aeroallergens.
FAU - Sunyer, J
AU  - Sunyer J
AD  - Departament d'Epidemiologia i Salut Publica, Institut Municipal d'Investigacio 
      Medica (IMIM), Barcelona, Spain.
FAU - Anto, J M
AU  - Anto JM
FAU - Castellsague, J
AU  - Castellsague J
FAU - Soriano, J B
AU  - Soriano JB
FAU - Roca, J
AU  - Roca J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Allergens)
RN  - 0 (Antibodies)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Allergens/immunology
MH  - Animals
MH  - Animals, Domestic/immunology
MH  - Antibodies/analysis/blood
MH  - Asthma/blood/*immunology/physiopathology
MH  - Bronchial Hyperreactivity/immunology
MH  - Bronchial Provocation Tests
MH  - Bronchoconstrictor Agents/administration & dosage
MH  - Cohort Studies
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Forced Expiratory Volume
MH  - Fungi/immunology
MH  - Humans
MH  - Hypersensitivity/immunology
MH  - Immunoglobulin E/analysis/*blood
MH  - Male
MH  - Methacholine Chloride/administration & dosage
MH  - Mites/immunology
MH  - Respiratory Sounds/immunology
MH  - Sex Factors
MH  - Smoking
MH  - Spain
MH  - Spirometry
MH  - Surveys and Questionnaires
EDAT- 1996/09/01 00:00
MHDA- 1996/09/01 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1996/09/01 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1183/09031936.96.09091880 [doi]
PST - ppublish
SO  - Eur Respir J. 1996 Sep;9(9):1880-4. doi: 10.1183/09031936.96.09091880.