PMID- 8880629
OWN - NLM
STAT- MEDLINE
DCOM- 19970123
LR  - 20190920
IS  - 0300-5577 (Print)
IS  - 0300-5577 (Linking)
VI  - 24
IP  - 4
DP  - 1996
TI  - Doppler velocimetry of different sections of the fetal middle cerebral artery in 
      relation to perinatal outcome.
PG  - 327-34
AB  - To assess the standard curves of pulsatility index (PI) in different segments of 
      middle cerebral artery (MCA): initial segment (MI) and subcortical segment (M2); 
      to determine the variation of the flow velocity waveforms (FVW) of the M1 and M2 
      segments of MCA in presence of fetal distress and to establish the possible 
      correlation between the two segments of MCA. 50 normal pregnancies from 25 weeks 
      of gestation to term and 20 pregnancy with alteration of fetal growth rate were 
      investigated with serial records of the FVW of the M1 and M2 segments of the MCA 
      and of the umbilical artery (UA) with a colour Doppler system. Severe fetal 
      distress was associated to cerebral-placental ratio below 1 (C/P < 1). The 
      perinatal outcome was established on the basis: 1) abnormal intrapartum CTG, 2) 
      emergency cesarean section, 3) Apgar score at 1st and 5th minute after birth and 
      4) birth eight centiles. In normal pregnancy P1 of M2 was always higher than that 
      of M1: therefore M2/M2 resulted below 1, with a maximum peak near 32 weeks of 
      gestation. In presence of moderate fetal distress only P1 of M2 was reduced 
      (M1/M2 > 1). It exists a significant difference of PI in M1 and M2 segments of 
      fetal MCA during gestation: thus MCA so it is important to identify the tract of 
      fetal MCA when recording its FVW. Moreover we suppose that an initial "cerebral 
      sparing" effect exists in order to protect the cortex by the initial hypoxic 
      injury: this is shown by a M1/M2 > 1. The progression of fetal distress results 
      in a greater haemodynamic modification, the so called "brain sparing" which is 
      usually present when C/P < 1.
FAU - Luzi, G
AU  - Luzi G
AD  - Institute of Gynecology and Obstetrics, University of Perugia, Italy.
FAU - Coata, G
AU  - Coata G
FAU - Caserta, G
AU  - Caserta G
FAU - Cosmi, E V
AU  - Cosmi EV
FAU - Di Renzo, G C
AU  - Di Renzo GC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - J Perinat Med
JT  - Journal of perinatal medicine
JID - 0361031
SB  - IM
MH  - Apgar Score
MH  - Birth Weight
MH  - Cardiotocography/statistics & numerical data
MH  - Cerebral Arteries/*diagnostic imaging/embryology
MH  - Cesarean Section/statistics & numerical data
MH  - Cohort Studies
MH  - Female
MH  - Fetal Growth Retardation/physiopathology
MH  - Gestational Age
MH  - Humans
MH  - *Laser-Doppler Flowmetry
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy Trimester, Second
MH  - Pregnancy Trimester, Third
MH  - Pulsatile Flow/*physiology
MH  - Reference Values
MH  - Ultrasonography
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1515/jpme.1996.24.4.327 [doi]
PST - ppublish
SO  - J Perinat Med. 1996;24(4):327-34. doi: 10.1515/jpme.1996.24.4.327.